Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061656552> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2061656552 abstract "Congenital heart disease (CHD) account for 1-3% population and ventricular septal defect (VSD) is the most common form of CHD that accounts for approximately 40% of total patients. Some of children with VSD can have spontaneous closure, but some don't. It is worth to study the biomarkers associated with VSD formation or closure. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases involved in breakdown, and physiological homeostasis of extracellular matrix. It has been reported that MMPs play the important roles in embryonic development, cardiomyocyte differentiation and causing cardiac tissue remodeling. Therefore, we studied the changes of plasma MMP-2 and MMP-9 activities in the patients with VSD.There were 96 children with perimembranous VSD enrolled in this study. We assigned our patients into three different groups according to the ratio of VSD diameter/diameter of aortic root (Ao). They were classified as below: Trivial group (VSD/Ao ratio < 0.2), Mild group (0.2 < VSD/Ao < 0.3), and Median group (0.3 < VSD/Ao). Plasma MMP-2 and MMP-9 activities of the patients were detected and assayed by gelatin zymography.The determined results show that there was a significant higher MMP-2 activity in the three groups when the results compared with that in the control group (p < 0.01). The changes of MMP-9 activity showed a similar trend as the finding in MMP-2 activity. After one year follow-up, it is found that significant difference of MMP-9 enzyme activity was found between VSD spontaneous closure and non-closure group (p < 0.01). In conclusion, a positive trend between the different size groups of VSD and activities of MMP-2 and MMP-9 was found. Our data hint that MMP-2 and MMP-9 expression may play a role in the pathogenesis of VSD. It is worth to further investigate the correlation between the changes of gelatinase and the mechanism of VSD formation or closure." @default.
- W2061656552 created "2016-06-24" @default.
- W2061656552 creator A5000175803 @default.
- W2061656552 creator A5008041673 @default.
- W2061656552 creator A5054137637 @default.
- W2061656552 creator A5062858773 @default.
- W2061656552 date "2013-08-02" @default.
- W2061656552 modified "2023-09-28" @default.
- W2061656552 title "The changes of matrix metalloproteinase-2 and -9 enzyme activities in the children with ventricular septal defect" @default.
- W2061656552 doi "https://doi.org/10.1093/eurheartj/eht309.p3894" @default.
- W2061656552 hasPublicationYear "2013" @default.
- W2061656552 type Work @default.
- W2061656552 sameAs 2061656552 @default.
- W2061656552 citedByCount "0" @default.
- W2061656552 crossrefType "journal-article" @default.
- W2061656552 hasAuthorship W2061656552A5000175803 @default.
- W2061656552 hasAuthorship W2061656552A5008041673 @default.
- W2061656552 hasAuthorship W2061656552A5054137637 @default.
- W2061656552 hasAuthorship W2061656552A5062858773 @default.
- W2061656552 hasBestOaLocation W20616565521 @default.
- W2061656552 hasConcept C109523444 @default.
- W2061656552 hasConcept C126322002 @default.
- W2061656552 hasConcept C134018914 @default.
- W2061656552 hasConcept C164705383 @default.
- W2061656552 hasConcept C177430391 @default.
- W2061656552 hasConcept C185592680 @default.
- W2061656552 hasConcept C189165786 @default.
- W2061656552 hasConcept C2908647359 @default.
- W2061656552 hasConcept C55493867 @default.
- W2061656552 hasConcept C63645605 @default.
- W2061656552 hasConcept C71924100 @default.
- W2061656552 hasConcept C99454951 @default.
- W2061656552 hasConceptScore W2061656552C109523444 @default.
- W2061656552 hasConceptScore W2061656552C126322002 @default.
- W2061656552 hasConceptScore W2061656552C134018914 @default.
- W2061656552 hasConceptScore W2061656552C164705383 @default.
- W2061656552 hasConceptScore W2061656552C177430391 @default.
- W2061656552 hasConceptScore W2061656552C185592680 @default.
- W2061656552 hasConceptScore W2061656552C189165786 @default.
- W2061656552 hasConceptScore W2061656552C2908647359 @default.
- W2061656552 hasConceptScore W2061656552C55493867 @default.
- W2061656552 hasConceptScore W2061656552C63645605 @default.
- W2061656552 hasConceptScore W2061656552C71924100 @default.
- W2061656552 hasConceptScore W2061656552C99454951 @default.
- W2061656552 hasLocation W20616565521 @default.
- W2061656552 hasOpenAccess W2061656552 @default.
- W2061656552 hasPrimaryLocation W20616565521 @default.
- W2061656552 hasRelatedWork W1970676458 @default.
- W2061656552 hasRelatedWork W1990006337 @default.
- W2061656552 hasRelatedWork W2009111655 @default.
- W2061656552 hasRelatedWork W2012649825 @default.
- W2061656552 hasRelatedWork W2012684840 @default.
- W2061656552 hasRelatedWork W2014516256 @default.
- W2061656552 hasRelatedWork W2027738223 @default.
- W2061656552 hasRelatedWork W2031192744 @default.
- W2061656552 hasRelatedWork W2031249707 @default.
- W2061656552 hasRelatedWork W2065643549 @default.
- W2061656552 hasRelatedWork W2151325439 @default.
- W2061656552 hasRelatedWork W2170419388 @default.
- W2061656552 hasRelatedWork W2313751573 @default.
- W2061656552 hasRelatedWork W2348122056 @default.
- W2061656552 hasRelatedWork W2363518746 @default.
- W2061656552 hasRelatedWork W2365788600 @default.
- W2061656552 hasRelatedWork W2388958853 @default.
- W2061656552 hasRelatedWork W2465470466 @default.
- W2061656552 hasRelatedWork W3045522455 @default.
- W2061656552 hasRelatedWork W2473611617 @default.
- W2061656552 isParatext "false" @default.
- W2061656552 isRetracted "false" @default.
- W2061656552 magId "2061656552" @default.
- W2061656552 workType "article" @default.