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• W2061657649 abstract "Flavone and 10 hydroxy and glucoside flavone derivatives were synthesised. They were tested for their analgesic effect in mice employing acetic acid-induced writhing and tail immersion methods. Subcutaneously all the tested compounds exhibited significant analgesic activity with varying potencies in both assay models. The activity of flavone and its 5-; 7-; 2'-; 5,7- and 7,8-hydroxy derivatives apparently involves an opiate-like mechanism, since their activity was reversed by naloxone pretreatment. It is suggested that flavonoid substances may utilise more than one mechanism in eliciting analgesia." @default.
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• W2061657649 date "1990-02-01" @default.
• W2061657649 modified "2023-10-01" @default.
• W2061657649 title "Analgesic activity of certain flavone derivatives: A structure-activity study" @default.
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• W2061657649 doi "https://doi.org/10.1016/0378-8741(90)90030-w" @default.
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