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- W2061659587 abstract "Abstract To better characterize the relationship between GABA and benzodiazepine receptors, the phylogenetic properties of muscimol-activated benzodiazepine receptor binding in vertebrate brain were examined. Muscimol enhanced 3 H-diazepam binding to brain membranes of all vertebrates studied, except the hagfish, a species known to possess GABA receptors, but where neither basal, nor activated 3 H-diazepam binding were observed. In responding tissues, the magnitude of the increase varied with the relative density of benzodiazepine receptors. Furthermore, the potency of muscimol to enhance 3 H-diazepam binding appears to be substantially greater in human brain than in other species. These findings suggest that benzodiazepine and GABA receptors developed independently and that most, if not all, benzodiazepine receptors are coupled to GABA receptors with the coupling being most efficient in human brain." @default.
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- W2061659587 date "1980-01-01" @default.
- W2061659587 modified "2023-09-28" @default.
- W2061659587 title "Phylogenetic characteristics of muscimol-activated benzodiazepine receptor binding" @default.
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- W2061659587 doi "https://doi.org/10.1016/0361-9230(80)90029-5" @default.
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