Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061671517> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2061671517 endingPage "1051" @default.
- W2061671517 startingPage "1047" @default.
- W2061671517 abstract "2(R,S)-5,5-Trimethylthiazolidine-4-(S)-carboxylic acid (1a), with a 3.3 to 1 predominance of the 2S (cis) isomer, was shown to epimerize at the C-2 position in neutral, protic solvents. This was manifested by mutarotation concomitant to changes in the ratios of the C-4 methine proton resonances in the nmr spectrum. Compound 1a was stable in dilute sodium carbonate solution, but underwent rapid equilibration in 1N hydrochloric acid. Acetylation of 1a gave an acetyl derivative (2a) with exclusively 2S,4S stereochemistry. Chiral integrity at C-2 was proved by conversion of both 2a and its enantiomer 2b via their munchnone derivatives to enantiomeric dimethyl 1,1,3,5-tetramethyl-1H,2H-pyrrolo[1,2-c]thiazole-6,7-dicarboxylates (4a and 4b). Acetylation of 2-(R,S)-phenyl-5,5-dimethylthiazolidine-4(S)-carboxylic acid, afforded both the 2S,4S (6a) and 2R,4S (6b) epimers. Epimerization of 6a at C-4 gave the 2S,4R isomer (6c) which was enantiomeric with 6b." @default.
- W2061671517 created "2016-06-24" @default.
- W2061671517 creator A5000844606 @default.
- W2061671517 creator A5004521857 @default.
- W2061671517 creator A5042009139 @default.
- W2061671517 date "1981-08-01" @default.
- W2061671517 modified "2023-10-16" @default.
- W2061671517 title "Epimerization at C-2 of 2-substituted thiazolidine-4-carboxylic acids" @default.
- W2061671517 cites W1494752617 @default.
- W2061671517 cites W1572097891 @default.
- W2061671517 cites W1972421899 @default.
- W2061671517 cites W1974377399 @default.
- W2061671517 cites W1978100568 @default.
- W2061671517 cites W1985783154 @default.
- W2061671517 cites W1991544017 @default.
- W2061671517 cites W2001460680 @default.
- W2061671517 cites W2002015008 @default.
- W2061671517 cites W2008260205 @default.
- W2061671517 cites W2011984917 @default.
- W2061671517 cites W2015555956 @default.
- W2061671517 cites W2021768551 @default.
- W2061671517 cites W2026897812 @default.
- W2061671517 cites W2057190675 @default.
- W2061671517 cites W2058717723 @default.
- W2061671517 cites W2067505316 @default.
- W2061671517 cites W2069061366 @default.
- W2061671517 cites W2099205156 @default.
- W2061671517 cites W2138210137 @default.
- W2061671517 cites W2312668378 @default.
- W2061671517 cites W2314896070 @default.
- W2061671517 cites W2321906419 @default.
- W2061671517 cites W2322697410 @default.
- W2061671517 cites W2324160006 @default.
- W2061671517 cites W2325305533 @default.
- W2061671517 cites W3025394620 @default.
- W2061671517 cites W39237383 @default.
- W2061671517 doi "https://doi.org/10.1002/jhet.5570180538" @default.
- W2061671517 hasPublicationYear "1981" @default.
- W2061671517 type Work @default.
- W2061671517 sameAs 2061671517 @default.
- W2061671517 citedByCount "42" @default.
- W2061671517 countsByYear W20616715172016 @default.
- W2061671517 countsByYear W20616715172017 @default.
- W2061671517 countsByYear W20616715172018 @default.
- W2061671517 countsByYear W20616715172021 @default.
- W2061671517 crossrefType "journal-article" @default.
- W2061671517 hasAuthorship W2061671517A5000844606 @default.
- W2061671517 hasAuthorship W2061671517A5004521857 @default.
- W2061671517 hasAuthorship W2061671517A5042009139 @default.
- W2061671517 hasConcept C155647269 @default.
- W2061671517 hasConcept C178790620 @default.
- W2061671517 hasConcept C185592680 @default.
- W2061671517 hasConcept C203130289 @default.
- W2061671517 hasConcept C2776590680 @default.
- W2061671517 hasConcept C2776612806 @default.
- W2061671517 hasConcept C2778896499 @default.
- W2061671517 hasConcept C2779074116 @default.
- W2061671517 hasConcept C486523 @default.
- W2061671517 hasConcept C60002323 @default.
- W2061671517 hasConcept C71240020 @default.
- W2061671517 hasConceptScore W2061671517C155647269 @default.
- W2061671517 hasConceptScore W2061671517C178790620 @default.
- W2061671517 hasConceptScore W2061671517C185592680 @default.
- W2061671517 hasConceptScore W2061671517C203130289 @default.
- W2061671517 hasConceptScore W2061671517C2776590680 @default.
- W2061671517 hasConceptScore W2061671517C2776612806 @default.
- W2061671517 hasConceptScore W2061671517C2778896499 @default.
- W2061671517 hasConceptScore W2061671517C2779074116 @default.
- W2061671517 hasConceptScore W2061671517C486523 @default.
- W2061671517 hasConceptScore W2061671517C60002323 @default.
- W2061671517 hasConceptScore W2061671517C71240020 @default.
- W2061671517 hasIssue "5" @default.
- W2061671517 hasLocation W20616715171 @default.
- W2061671517 hasOpenAccess W2061671517 @default.
- W2061671517 hasPrimaryLocation W20616715171 @default.
- W2061671517 hasRelatedWork W1995055066 @default.
- W2061671517 hasRelatedWork W2015070681 @default.
- W2061671517 hasRelatedWork W2025988024 @default.
- W2061671517 hasRelatedWork W2061671517 @default.
- W2061671517 hasRelatedWork W2087224582 @default.
- W2061671517 hasRelatedWork W2131612744 @default.
- W2061671517 hasRelatedWork W2231468581 @default.
- W2061671517 hasRelatedWork W2949458489 @default.
- W2061671517 hasRelatedWork W2949676535 @default.
- W2061671517 hasRelatedWork W2949861160 @default.
- W2061671517 hasVolume "18" @default.
- W2061671517 isParatext "false" @default.
- W2061671517 isRetracted "false" @default.
- W2061671517 magId "2061671517" @default.
- W2061671517 workType "article" @default.