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• W2061680825 abstract "Significance X-ray crystallography greatly benefits drug discovery work by elucidating information about the binding of drug compounds to their target. Using this information, changes to the compounds can be made in a process known as rational drug design. Cytochrome bc 1 is a proven drug target in the treatment and prevention of malaria, a disease that kills over half a million people each year and many compounds have been developed to inhibit cytochrome bc 1 . Here we show the binding of two such compounds in X-ray crystal structures, which reveal an unexpected binding site. This work opens up a new area for antimalarial research and reinforces the need for structural information in drug design." @default.
• W2061680825 created "2016-06-24" @default.
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• W2061680825 date "2015-01-06" @default.
• W2061680825 modified "2023-10-16" @default.
• W2061680825 title "Antimalarial 4(1H)-pyridones bind to the Q _i site of cytochrome <i>bc</i> ₁" @default.
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• W2061680825 doi "https://doi.org/10.1073/pnas.1416611112" @default.
• W2061680825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4311836" @default.
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