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- W2061689404 abstract "<h3>To the Editor.—</h3> Aicardi's syndrome is an easily recognizable entity that is characterized by infantile spasms, agenesis of corpus callosum, chorioretinal lacunae, mental subnormality, vertebral abnormalities, and poor life expectancy.<sup>1-3</sup>It occurs only in females. Its cause eludes us. Influenza<sup>4</sup>and cytomegalovirus infection<sup>5</sup>have been implicated. X-chromosomal-dominant inheritance with manifestation in the heterozygote, the gene being male-lethal,<sup>1</sup>or a multiple gene defect,<sup>1,6</sup>have been proposed. I studied a case in which corticosteroids may have been a factor. <h3>Report of a Case.—</h3> A 12-month-old girl was admitted to the hospital with multiple craniofacial and vertebral anomalies. She was born to a gravida 5, para 4, abortus 1, 34-year-old nurse who has multiple sclerosis. At eight weeks, the pregnancy was complicated by a relapse of multiple sclerosis, for which 80 units of adrenocorticotropic hormone was given daily for ten days. The rest of the pregnancy was uneventful." @default.
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- W2061689404 date "1981-01-01" @default.
- W2061689404 modified "2023-09-25" @default.
- W2061689404 title "Aicardi's Syndrome: Are Corticosteroids Teratogens?" @default.
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- W2061689404 doi "https://doi.org/10.1001/archneur.1981.00510010096035" @default.
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