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• W2061709897 abstract "Corticotropin-releasing hormone was first identified by Vale et al 1 Vale W Spiess J Rivier C Rivier J Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotrophin and beta-endorphin. Science. 1981; 213: 1394-1397 Crossref PubMed Scopus (3992) Google Scholar in 1981. The peptide, found in the hypothalamus, was defined by its ability to stimulate adrenocorticotropic hormone released from the anterior pituitary. However, in 1982 corticotropin-releasing hormone was identified within the human placenta, and 2 years later high concentrations were reported in the plasma of women during the third trimester of pregnancy. 2 Sasaki A Shinkawa O Margioris AN Liotta AS Sato S Murakami O et al. Immunoreactive corticotropin-releasing hormone in human plasma during pregnancy, labor, and delivery. J Clin Endocrinol Metab. 1987; 64: 224-229 Crossref PubMed Scopus (235) Google Scholar Initial studies performed in our laboratory on extracts of human placenta and pregnant women’s blood revealed patterns quite different from those found in hypothalamus 3 Chan E-C Thomson M Madsen G Falconer J Smith R Differential processing of corticotropin-releasing hormone by the human placenta and hypothalamus. Biochem Biophys Res Commun. 1998; 153: 1229-1235 Crossref Scopus (28) Google Scholar . In the hypothalamus, the vast majority of immunoreactive corticotropin-releasing hormone coelutes with standard 41–amino acid corticotropin-releasing hormone, but in the placenta much of the immunoreactive corticotropin-releasing hormone is bound to a binding protein (corticotropin-releasing hormone binding protein, identified by the groups of Lowry and Vale 4 Potter E Behan DP Fischer WH Linton EA Lowry PJ Vale WW Cloning and characterization of the cDNAs for human and rat corticotrophin releasing factor–binding proteins. Nature. 1991; 349: 423-426 Crossref PubMed Scopus (320) Google Scholar ) and an intermediate-size peak, which may represent a corticotropin-releasing hormone precursor, is also found. These data are consistent with the storage of large amounts of mature corticotropin-releasing hormone within secretory vesicles in the hypothalamus. In contrast, within the placenta it appears that a relatively small proportion of corticotropin-releasing hormone is in the mature process peptide form within secretory vesicles, suggesting that corticotropin-releasing hormone secretion is occurring through a process more consistent with constitutive secretion than with regulated exocytosis." @default.
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• W2061709897 title "Corticotropin-releasing hormone and the fetoplacental clock: An Australian perspective" @default.
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• W2061709897 doi "https://doi.org/10.1016/s0002-9378(99)70715-5" @default.
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