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- W2061721293 abstract "A cDNA encoding a mouse B 2 bradykinin (BK) receptor was stably transfected in Chinese hamster ovary (CHO) cells. In two resulting transformants, mouse B 2 BK receptor was found to induce a twofold elevation in the inositol-1,4,5-trisphosphate level. In a pertussis toxin-insensitive manner, BK also produced a biphasic increase in the intracellular Ca 2+ concentration ([Ca 2+ ] i ). The initial elevation in [Ca 2+ ] i was abolished by thapsigargin pretreatment in Ca 2+ -free medium. The second phase was dependent on external Ca 2+ . The BK/inositol trisphosphate- and thapsigargin-sensitive Ca 2+ stores required extracellular Ca 2+ for refilling. Ca 2+ influx induced by BK and thapsigargin was confirmed by Mn 2+ entry through Ca 2+ influx pathways producing Mn 2+ quenching. Genistein, a tyrosine kinase inhibitor, partially decreased the BK-induced [Ca 2+ ] i increase during the sustained phase and the rate of Mn 2+ entry. BK had essentially no effect on the intracellular cyclic AMP level. The results suggest that the mouse B 2 BK receptor couples to phospholipase C in CHO cells and that its activation results in biphasic [Ca 2+ ] i increases, by mobilization of intracellular Ca 2+ and store-depletion-mediated Ca 2+ influx, the latter of which is tyrosine phosphorylation-dependent." @default.
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- W2061721293 date "1997-01-01" @default.
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- W2061721293 title "Ca2+ release and Ca2+ influx in Chinese hamster ovary cells expressing the cloned mouse B2 bradykinin receptor: tyrosine kinase inhibitor-sensitive and -insensitive processes" @default.
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- W2061721293 doi "https://doi.org/10.1016/s0167-4889(96)00126-7" @default.
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