FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061723568> ?p ?o ?g. }

• W2061723568 endingPage "96" @default.
• W2061723568 startingPage "92" @default.
• W2061723568 abstract "Extracellular ATP is a signaling molecule that often serves as a danger signal to alert the immune system of tissue damage. This molecule activates P2 nucleotide receptors, that include the ionotropic P2X receptors and metabotropic P2Y receptors. Recently, it has been reported that ATP accumulates in the airways of both asthmatic patients and sensitized mice after allergen challenge. The role and function of ATP in the pathogenesis of chronic obstructive pulmonary diseases (COPD) are not well understood. In this study we investigated the effect of cigarette smoke on purinergic receptors and ATP release by neutrophils. Neutrophils and their mediators are key players in the pathogenesis of lung emphysema. Here we demonstrated that in an in vivo model of cigarette smoke-induced lung emphysema, the amount of ATP was increased in the bronchoalveolar lavage fluid. Moreover, activation of neutrophils with cigarette smoke extract induced ATP release. Treatment of neutrophils with apyrase (catalyses the hydrolysis of ATP to yield AMP) and suramin (P2-receptor antagonist) abrogated the release of CXCL8 and elastase induced by cigarette smoke extract and exogenous ATP. These observations indicate that activation of purinergic signaling by cigarette smoke may take part in the pathogenesis of lung emphysema." @default.
• W2061723568 created "2016-06-24" @default.
• W2061723568 creator A5049224896 @default.
• W2061723568 creator A5069659223 @default.
• W2061723568 creator A5069877180 @default.
• W2061723568 creator A5077892254 @default.
• W2061723568 creator A5078227567 @default.
• W2061723568 creator A5079207850 @default.
• W2061723568 date "2009-10-01" @default.
• W2061723568 modified "2023-10-14" @default.
• W2061723568 title "ATP in the pathogenesis of lung emphysema" @default.
• W2061723568 cites W1502595840 @default.
• W2061723568 cites W1965451386 @default.
• W2061723568 cites W1982230576 @default.
• W2061723568 cites W1984428604 @default.
• W2061723568 cites W1987062630 @default.
• W2061723568 cites W2034646156 @default.
• W2061723568 cites W2042906495 @default.
• W2061723568 cites W2059446798 @default.
• W2061723568 cites W2079116154 @default.
• W2061723568 cites W2084643753 @default.
• W2061723568 cites W2096539359 @default.
• W2061723568 cites W2101182707 @default.
• W2061723568 cites W2105843214 @default.
• W2061723568 cites W2106752489 @default.
• W2061723568 cites W2117975450 @default.
• W2061723568 cites W2125828034 @default.
• W2061723568 cites W2127823826 @default.
• W2061723568 cites W2137141750 @default.
• W2061723568 cites W2140764802 @default.
• W2061723568 cites W2149362097 @default.
• W2061723568 cites W2171678969 @default.
• W2061723568 cites W2236421686 @default.
• W2061723568 cites W4211164169 @default.
• W2061723568 doi "https://doi.org/10.1016/j.ejphar.2009.07.022" @default.
• W2061723568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19654006" @default.
• W2061723568 hasPublicationYear "2009" @default.
• W2061723568 type Work @default.
• W2061723568 sameAs 2061723568 @default.
• W2061723568 citedByCount "58" @default.
• W2061723568 countsByYear W20617235682012 @default.
• W2061723568 countsByYear W20617235682013 @default.
• W2061723568 countsByYear W20617235682014 @default.
• W2061723568 countsByYear W20617235682015 @default.
• W2061723568 countsByYear W20617235682016 @default.
• W2061723568 countsByYear W20617235682017 @default.
• W2061723568 countsByYear W20617235682018 @default.
• W2061723568 countsByYear W20617235682019 @default.
• W2061723568 countsByYear W20617235682020 @default.
• W2061723568 countsByYear W20617235682022 @default.
• W2061723568 crossrefType "journal-article" @default.
• W2061723568 hasAuthorship W2061723568A5049224896 @default.
• W2061723568 hasAuthorship W2061723568A5069659223 @default.
• W2061723568 hasAuthorship W2061723568A5069877180 @default.
• W2061723568 hasAuthorship W2061723568A5077892254 @default.
• W2061723568 hasAuthorship W2061723568A5078227567 @default.
• W2061723568 hasAuthorship W2061723568A5079207850 @default.
• W2061723568 hasConcept C115955781 @default.
• W2061723568 hasConcept C160225129 @default.
• W2061723568 hasConcept C170493617 @default.
• W2061723568 hasConcept C172590197 @default.
• W2061723568 hasConcept C185592680 @default.
• W2061723568 hasConcept C203014093 @default.
• W2061723568 hasConcept C26702167 @default.
• W2061723568 hasConcept C2776182878 @default.
• W2061723568 hasConcept C2778938600 @default.
• W2061723568 hasConcept C2779508331 @default.
• W2061723568 hasConcept C2780019924 @default.
• W2061723568 hasConcept C2780410667 @default.
• W2061723568 hasConcept C2780942790 @default.
• W2061723568 hasConcept C55493867 @default.
• W2061723568 hasConcept C57306754 @default.
• W2061723568 hasConcept C61174792 @default.
• W2061723568 hasConcept C67907053 @default.
• W2061723568 hasConcept C71924100 @default.
• W2061723568 hasConcept C98274493 @default.
• W2061723568 hasConceptScore W2061723568C115955781 @default.
• W2061723568 hasConceptScore W2061723568C160225129 @default.
• W2061723568 hasConceptScore W2061723568C170493617 @default.
• W2061723568 hasConceptScore W2061723568C172590197 @default.
• W2061723568 hasConceptScore W2061723568C185592680 @default.
• W2061723568 hasConceptScore W2061723568C203014093 @default.
• W2061723568 hasConceptScore W2061723568C26702167 @default.
• W2061723568 hasConceptScore W2061723568C2776182878 @default.
• W2061723568 hasConceptScore W2061723568C2778938600 @default.
• W2061723568 hasConceptScore W2061723568C2779508331 @default.
• W2061723568 hasConceptScore W2061723568C2780019924 @default.
• W2061723568 hasConceptScore W2061723568C2780410667 @default.
• W2061723568 hasConceptScore W2061723568C2780942790 @default.
• W2061723568 hasConceptScore W2061723568C55493867 @default.
• W2061723568 hasConceptScore W2061723568C57306754 @default.
• W2061723568 hasConceptScore W2061723568C61174792 @default.
• W2061723568 hasConceptScore W2061723568C67907053 @default.
• W2061723568 hasConceptScore W2061723568C71924100 @default.
• W2061723568 hasConceptScore W2061723568C98274493 @default.
• W2061723568 hasIssue "1-3" @default.
• W2061723568 hasLocation W20617235681 @default.
• W2061723568 hasLocation W20617235682 @default.

• next