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• W2061736304 abstract "Apoptosis induced by toxic bile acids is thought to contribute to liver injury during cholestasis. The transcription factor AP-1 is involved in the induction of apoptosis depending on stimulus and cell type. It is not known whether the major human toxic bile acid, glycochenodeoxycholic acid (GCDCA), modulates AP-1 in hepatocytes. Our data show that GCDCA (75 μM, 4 h) significantly upregulates cFos and JunB as demonstrated by microarray analysis and real-time PCR in HepG2-Ntcp hepatoma cells. GCDCA (75 μM, 4 h) also induced AP-1 activation as determined by EMSA that was most distinct after 30 min. In parallel, AP-1 transcriptional activity increased by 40% after exposure to GCDCA. Curcumin, an AP-1 inhibitor, dose-dependently reduced (1–25 μM) or completely abolished (50 μM) the apoptotic effect of GCDCA. Thus, GCDCA-induced upregulation of AP-1-dependent genes appears important for the cytotoxicity of this bile acid." @default.
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• W2061736304 date "2006-02-01" @default.
• W2061736304 modified "2023-10-15" @default.
• W2061736304 title "The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis" @default.
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• W2061736304 doi "https://doi.org/10.1016/j.bbrc.2005.12.081" @default.
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