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- W2061740109 abstract "Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase ( lck ) promoter were used to analyze critical aspects of the immune system, including patterns of T cell development and T cell homing after transplant. GFP-labeled T cells could be ablated in larvae by either irradiation or dexamethasone added to the water, illustrating that T cells have evolutionarily conserved responses to chemical and radiation ablation. In transplant experiments, thymocytes from lck-GFP fish repopulated the thymus of irradiated wild-type fish only transiently, suggesting that the thymus contains only short-term thymic repopulating cells. By contrast, whole kidney marrow permanently reconstituted the T lymphoid compartment of irradiated wild-type fish, suggesting that long-term thymic repopulating cells reside in the kidney." @default.
- W2061740109 created "2016-06-24" @default.
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- W2061740109 date "2004-05-03" @default.
- W2061740109 modified "2023-10-03" @default.
- W2061740109 title "<i>In vivo</i> tracking of T cell development, ablation, and engraftment in transgenic zebrafish" @default.
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- W2061740109 doi "https://doi.org/10.1073/pnas.0402248101" @default.
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