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- W2061742377 abstract "AP-2 is a family of transcription factors that play important roles during embryonic development. Two AP-2 genes, AP-2α and AP-2β, have previously been characterized in chick retina. Here, we demonstrate that a third member of the chicken AP-2 family, AP-2δ, is primarily expressed in the retina and brain, with highest levels at embryonic days 7 to 11. By in situ hybridization and immunohistochemical analysis, we show that AP-2δ RNA and protein are found in a subset of ganglion cells in embryonic chick retina. Co-immunostaining with anti-Brn3a and anti–AP-2δ antibodies indicates that approximately one-third of Brn3a-positive ganglion cells express AP-2δ. AP-2δ RNA but not AP-2δ protein is also found in cells located in the outer half of the inner nuclear layer. The spatial and temporal distribution of AP-2δ protein in the retina suggests a transient role in a subset of late-born ganglion cells likely involving axonal trafficking or pathfinding. Developmental Dynamics 237:3210–3221, 2008. © 2008 Wiley-Liss, Inc." @default.
- W2061742377 created "2016-06-24" @default.
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- W2061742377 date "2008-11-01" @default.
- W2061742377 modified "2023-09-23" @default.
- W2061742377 title "Expression of AP-2δ in the developing chick retina" @default.
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- W2061742377 doi "https://doi.org/10.1002/dvdy.21744" @default.
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