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- W2061746816 abstract "Current vaccination strategies mainly target antigens into the phagosomal, major histocompatibility complex class II antigen-processing pathway and thus lead predominantly to humoral immune responses. The elicitation of cytotoxic T-cell responses instead requires introduction of antigens into the cytosol of professional antigen-presenting cells (APCs). The intracellular bacterium Listeria monocytogenes gains access to the host cell cytosol by means of a cytolysin, listeriolysin O. Vaccine researchers have successfully employed listeriolysin in novel vaccination approaches to provide access to the cytosol of professional APCs for purified protein antigens, attenuated bacterial vaccine strains, DNA vaccines and liposome contents." @default.
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- W2061746816 date "2001-01-01" @default.
- W2061746816 modified "2023-09-26" @default.
- W2061746816 title "From evil to good: a cytolysin in vaccine development" @default.
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- W2061746816 doi "https://doi.org/10.1016/s0966-842x(00)01893-x" @default.
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