FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061750240> ?p ?o ?g. }

• W2061750240 endingPage "1737" @default.
• W2061750240 startingPage "1731" @default.
• W2061750240 abstract "Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a 7-transmembrane receptor reportedly expressed in stem cells of the intestinal crypts and hair follicles of mice. Overexpression of LGR5 is observed in some types of cancer; however, there has been no specific assessment in colorectal tumorigenesis. We performed quantitative RT-PCR for LGR5 expression in 37 representative cancer cell lines, and showed that LGR5 mRNA was frequently overexpressed in colon cancer cell lines. Moreover, LGR5 expression was higher in colon cancer cell lines derived from metastatic tumors compared with those from primary tumors. In clinical specimens, there was significant overexpression of LGR5 in 35 of 50 colorectal cancers (CRCs), and in seven of seven sporadic colonic adenomas, compared with matched normal mucosa. This suggests up-regulation of LGR5 from the early stage of colorectal tumorigenesis. LGR5 expression showed marked variation among CRC cases and correlated significantly with lymphatic invasion, vascular invasion, tumor depth, lymph node metastasis, and tumor stage (IIIC vs. IIIB). In addition to cancer cells, crypt base columnar cells of the small intestine and colon were shown by in situ hybridization to express LGR5. This is the first report suggesting the involvement of LGR5, not only in early events but also in late events in colorectal tumorigenesis. (Cancer Sci 2010)" @default.
• W2061750240 created "2016-06-24" @default.
• W2061750240 creator A5014821917 @default.
• W2061750240 creator A5018112691 @default.
• W2061750240 creator A5020608796 @default.
• W2061750240 creator A5033113680 @default.
• W2061750240 creator A5049694850 @default.
• W2061750240 creator A5055536684 @default.
• W2061750240 creator A5062699449 @default.
• W2061750240 creator A5083486893 @default.
• W2061750240 creator A5091811703 @default.
• W2061750240 date "2010-03-24" @default.
• W2061750240 modified "2023-10-14" @default.
• W2061750240 title "Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer" @default.
• W2061750240 cites W1491616134 @default.
• W2061750240 cites W1965734230 @default.
• W2061750240 cites W1967137553 @default.
• W2061750240 cites W1971908496 @default.
• W2061750240 cites W1976206175 @default.
• W2061750240 cites W1982603620 @default.
• W2061750240 cites W1988867952 @default.
• W2061750240 cites W2002221745 @default.
• W2061750240 cites W2004891965 @default.
• W2061750240 cites W2005241408 @default.
• W2061750240 cites W2008557163 @default.
• W2061750240 cites W2017288002 @default.
• W2061750240 cites W2028080080 @default.
• W2061750240 cites W2040184671 @default.
• W2061750240 cites W2045956964 @default.
• W2061750240 cites W2058684884 @default.
• W2061750240 cites W2072158142 @default.
• W2061750240 cites W2090562908 @default.
• W2061750240 cites W2091723114 @default.
• W2061750240 cites W2093531978 @default.
• W2061750240 cites W2132705689 @default.
• W2061750240 cites W2136207147 @default.
• W2061750240 cites W2146167376 @default.
• W2061750240 cites W2153027227 @default.
• W2061750240 cites W2162102504 @default.
• W2061750240 cites W2163351051 @default.
• W2061750240 cites W2165844218 @default.
• W2061750240 cites W2171996338 @default.
• W2061750240 cites W1995216988 @default.
• W2061750240 doi "https://doi.org/10.1111/j.1349-7006.2010.01571.x" @default.
• W2061750240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20384634" @default.
• W2061750240 hasPublicationYear "2010" @default.
• W2061750240 type Work @default.
• W2061750240 sameAs 2061750240 @default.
• W2061750240 citedByCount "134" @default.
• W2061750240 countsByYear W20617502402012 @default.
• W2061750240 countsByYear W20617502402013 @default.
• W2061750240 countsByYear W20617502402014 @default.
• W2061750240 countsByYear W20617502402015 @default.
• W2061750240 countsByYear W20617502402016 @default.
• W2061750240 countsByYear W20617502402017 @default.
• W2061750240 countsByYear W20617502402018 @default.
• W2061750240 countsByYear W20617502402019 @default.
• W2061750240 countsByYear W20617502402020 @default.
• W2061750240 countsByYear W20617502402021 @default.
• W2061750240 countsByYear W20617502402022 @default.
• W2061750240 countsByYear W20617502402023 @default.
• W2061750240 crossrefType "journal-article" @default.
• W2061750240 hasAuthorship W2061750240A5014821917 @default.
• W2061750240 hasAuthorship W2061750240A5018112691 @default.
• W2061750240 hasAuthorship W2061750240A5020608796 @default.
• W2061750240 hasAuthorship W2061750240A5033113680 @default.
• W2061750240 hasAuthorship W2061750240A5049694850 @default.
• W2061750240 hasAuthorship W2061750240A5055536684 @default.
• W2061750240 hasAuthorship W2061750240A5062699449 @default.
• W2061750240 hasAuthorship W2061750240A5083486893 @default.
• W2061750240 hasAuthorship W2061750240A5091811703 @default.
• W2061750240 hasBestOaLocation W20617502401 @default.
• W2061750240 hasConcept C10116572 @default.
• W2061750240 hasConcept C121608353 @default.
• W2061750240 hasConcept C126322002 @default.
• W2061750240 hasConcept C136302470 @default.
• W2061750240 hasConcept C142724271 @default.
• W2061750240 hasConcept C2779013556 @default.
• W2061750240 hasConcept C28328180 @default.
• W2061750240 hasConcept C502942594 @default.
• W2061750240 hasConcept C526805850 @default.
• W2061750240 hasConcept C55427017 @default.
• W2061750240 hasConcept C555283112 @default.
• W2061750240 hasConcept C71924100 @default.
• W2061750240 hasConcept C86803240 @default.
• W2061750240 hasConcept C95444343 @default.
• W2061750240 hasConceptScore W2061750240C10116572 @default.
• W2061750240 hasConceptScore W2061750240C121608353 @default.
• W2061750240 hasConceptScore W2061750240C126322002 @default.
• W2061750240 hasConceptScore W2061750240C136302470 @default.
• W2061750240 hasConceptScore W2061750240C142724271 @default.
• W2061750240 hasConceptScore W2061750240C2779013556 @default.
• W2061750240 hasConceptScore W2061750240C28328180 @default.
• W2061750240 hasConceptScore W2061750240C502942594 @default.
• W2061750240 hasConceptScore W2061750240C526805850 @default.
• W2061750240 hasConceptScore W2061750240C55427017 @default.
• W2061750240 hasConceptScore W2061750240C555283112 @default.
• W2061750240 hasConceptScore W2061750240C71924100 @default.

• next