FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061765903> ?p ?o ?g. }

• W2061765903 endingPage "2157" @default.
• W2061765903 startingPage "2149" @default.
• W2061765903 abstract "H-Y encoded gene products were the first to be recognized as clinically relevant minor histocompatibility antigens. Compared to other gender combinations, female donor/male recipient (FDMR) transplants are associated with increased graft-versus-host disease (GvHD), increased transplant-related mortality (TRM) and reduced risk of relapse. Still, their relative impact on transplant outcome remains controversial. We analyzed donor/recipient sex combination in 53 988 patients treated with allogeneic hematopoietic stem cell transplantation (HSCT) between 1980 and 2005. We found a strong increase in chronic GvHD and late TRM and decreased survival in FDMR transplants irrespective of underlying disease. Conversely, FDMR patients had lower relapse rates. The negative effect on survival decreased with advancing disease stage as relapse protection became more important. Effects of H-Y alloreactivity were most pronounced in patients transplanted from HLA-matched donors and in those receiving transplants from an adult donor. Adjustment for acute and chronic GvHD only partially corrected the effects of H-Y alloreactivity. Analysis of the FDMR proportion over time indicated that the frequency of this gender combination has declined in unrelated transplants over the last 10 years. These data define the role of H-Y mismatching in allogeneic HSCT and support the current practice of avoiding female donors for male patients, if possible. H-Y encoded gene products were the first to be recognized as clinically relevant minor histocompatibility antigens. Compared to other gender combinations, female donor/male recipient (FDMR) transplants are associated with increased graft-versus-host disease (GvHD), increased transplant-related mortality (TRM) and reduced risk of relapse. Still, their relative impact on transplant outcome remains controversial. We analyzed donor/recipient sex combination in 53 988 patients treated with allogeneic hematopoietic stem cell transplantation (HSCT) between 1980 and 2005. We found a strong increase in chronic GvHD and late TRM and decreased survival in FDMR transplants irrespective of underlying disease. Conversely, FDMR patients had lower relapse rates. The negative effect on survival decreased with advancing disease stage as relapse protection became more important. Effects of H-Y alloreactivity were most pronounced in patients transplanted from HLA-matched donors and in those receiving transplants from an adult donor. Adjustment for acute and chronic GvHD only partially corrected the effects of H-Y alloreactivity. Analysis of the FDMR proportion over time indicated that the frequency of this gender combination has declined in unrelated transplants over the last 10 years. These data define the role of H-Y mismatching in allogeneic HSCT and support the current practice of avoiding female donors for male patients, if possible." @default.
• W2061765903 created "2016-06-24" @default.
• W2061765903 creator A5004985873 @default.
• W2061765903 creator A5007202804 @default.
• W2061765903 creator A5014510701 @default.
• W2061765903 creator A5020602973 @default.
• W2061765903 creator A5042734609 @default.
• W2061765903 creator A5058677948 @default.
• W2061765903 creator A5062465694 @default.
• W2061765903 creator A5072582820 @default.
• W2061765903 creator A5077430940 @default.
• W2061765903 date "2008-10-01" @default.
• W2061765903 modified "2023-10-02" @default.
• W2061765903 title "Female-Versus-Male Alloreactivity as a Model for Minor Histocompatibility Antigens in Hematopoietic Stem Cell Transplantation" @default.
• W2061765903 cites W1523409611 @default.
• W2061765903 cites W1534976948 @default.
• W2061765903 cites W1597029348 @default.
• W2061765903 cites W1970803003 @default.
• W2061765903 cites W1992275362 @default.
• W2061765903 cites W1999637787 @default.
• W2061765903 cites W2000922959 @default.
• W2061765903 cites W2005302631 @default.
• W2061765903 cites W2017386473 @default.
• W2061765903 cites W2022877662 @default.
• W2061765903 cites W2035800776 @default.
• W2061765903 cites W2071549635 @default.
• W2061765903 cites W2079215405 @default.
• W2061765903 cites W2096698918 @default.
• W2061765903 cites W2107697572 @default.
• W2061765903 cites W2127572475 @default.
• W2061765903 cites W2139184776 @default.
• W2061765903 cites W2141223501 @default.
• W2061765903 cites W2423054555 @default.
• W2061765903 doi "https://doi.org/10.1111/j.1600-6143.2008.02374.x" @default.
• W2061765903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18828773" @default.
• W2061765903 hasPublicationYear "2008" @default.
• W2061765903 type Work @default.
• W2061765903 sameAs 2061765903 @default.
• W2061765903 citedByCount "68" @default.
• W2061765903 countsByYear W20617659032012 @default.
• W2061765903 countsByYear W20617659032013 @default.
• W2061765903 countsByYear W20617659032014 @default.
• W2061765903 countsByYear W20617659032015 @default.
• W2061765903 countsByYear W20617659032016 @default.
• W2061765903 countsByYear W20617659032017 @default.
• W2061765903 countsByYear W20617659032018 @default.
• W2061765903 countsByYear W20617659032019 @default.
• W2061765903 countsByYear W20617659032020 @default.
• W2061765903 countsByYear W20617659032021 @default.
• W2061765903 countsByYear W20617659032022 @default.
• W2061765903 countsByYear W20617659032023 @default.
• W2061765903 crossrefType "journal-article" @default.
• W2061765903 hasAuthorship W2061765903A5004985873 @default.
• W2061765903 hasAuthorship W2061765903A5007202804 @default.
• W2061765903 hasAuthorship W2061765903A5014510701 @default.
• W2061765903 hasAuthorship W2061765903A5020602973 @default.
• W2061765903 hasAuthorship W2061765903A5042734609 @default.
• W2061765903 hasAuthorship W2061765903A5058677948 @default.
• W2061765903 hasAuthorship W2061765903A5062465694 @default.
• W2061765903 hasAuthorship W2061765903A5072582820 @default.
• W2061765903 hasAuthorship W2061765903A5077430940 @default.
• W2061765903 hasBestOaLocation W20617659031 @default.
• W2061765903 hasConcept C126322002 @default.
• W2061765903 hasConcept C147483822 @default.
• W2061765903 hasConcept C188280979 @default.
• W2061765903 hasConcept C202965653 @default.
• W2061765903 hasConcept C203014093 @default.
• W2061765903 hasConcept C207936829 @default.
• W2061765903 hasConcept C2777408962 @default.
• W2061765903 hasConcept C2779134260 @default.
• W2061765903 hasConcept C2779972918 @default.
• W2061765903 hasConcept C28328180 @default.
• W2061765903 hasConcept C2911091166 @default.
• W2061765903 hasConcept C48556533 @default.
• W2061765903 hasConcept C54355233 @default.
• W2061765903 hasConcept C71924100 @default.
• W2061765903 hasConcept C86803240 @default.
• W2061765903 hasConceptScore W2061765903C126322002 @default.
• W2061765903 hasConceptScore W2061765903C147483822 @default.
• W2061765903 hasConceptScore W2061765903C188280979 @default.
• W2061765903 hasConceptScore W2061765903C202965653 @default.
• W2061765903 hasConceptScore W2061765903C203014093 @default.
• W2061765903 hasConceptScore W2061765903C207936829 @default.
• W2061765903 hasConceptScore W2061765903C2777408962 @default.
• W2061765903 hasConceptScore W2061765903C2779134260 @default.
• W2061765903 hasConceptScore W2061765903C2779972918 @default.
• W2061765903 hasConceptScore W2061765903C28328180 @default.
• W2061765903 hasConceptScore W2061765903C2911091166 @default.
• W2061765903 hasConceptScore W2061765903C48556533 @default.
• W2061765903 hasConceptScore W2061765903C54355233 @default.
• W2061765903 hasConceptScore W2061765903C71924100 @default.
• W2061765903 hasConceptScore W2061765903C86803240 @default.
• W2061765903 hasIssue "10" @default.
• W2061765903 hasLocation W20617659031 @default.
• W2061765903 hasLocation W20617659032 @default.
• W2061765903 hasOpenAccess W2061765903 @default.
• W2061765903 hasPrimaryLocation W20617659031 @default.
• W2061765903 hasRelatedWork W1615700017 @default.

• next