Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061768189> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2061768189 endingPage "205" @default.
- W2061768189 startingPage "201" @default.
- W2061768189 abstract "Psoralens are tricyclic furocoumarins with potent photosensitizing properties in the skin and are now widely used in the treatment of several dermatologic diseases. In this study the effect of 3 different psoralens 8-methoxypsoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) and isopsoralen on hepatic microsomal drug-metabolizing enzymes and cytochrome P-450 has been assessed in mice and rats. 8-MOP administered orally to CD-1 mice daily for 6 days caused 2-3 fold increases in hepatic aryl hydrocarbon hydroxylase (AHH), ethylmorphine N-demethylase and cytochrome P-450. The absorbance maximum of the induced cytochrome was at 450 nm. Aniline hydroxylase activity was unchanged. Chronic administration of 8-MOP to hairless mice caused significant enhancement of hepatic ethylmorphine N-demethylase and cytochrome P-450 but had no effect on AHH; whereas chronically administered TMP had no significant effect on any of these parameters. Isopsoralen and TMP administered orally to CD-1 mice daily for 6 days had no effect on any of these liver enzymes or on hepatic P-450. 8-MOP administered daily for 6 days to rats caused a greater than 4-fold enhancement of AHH and greater than 2-fold enhancement of ethylmorphine N-demethylase and cytochrome P-450. These studies indicate that orally administered 8-MOP induces hepatic drug-metabolizing enzymes and cytochrome P-450 to a lesser extent than do the barbituates and suggest that this drug could influence the rate of biotransformation of concomitantly administered drugs in patients undergoing PUVA therapy." @default.
- W2061768189 created "2016-06-24" @default.
- W2061768189 creator A5003753703 @default.
- W2061768189 creator A5028792227 @default.
- W2061768189 creator A5076875729 @default.
- W2061768189 creator A5082425428 @default.
- W2061768189 date "1982-09-01" @default.
- W2061768189 modified "2023-09-24" @default.
- W2061768189 title "The Effect of Psoralens on Hepatic and Cutaneous Drug Metabolizing Enzymes and Cytochrome P-450" @default.
- W2061768189 cites W1532309638 @default.
- W2061768189 cites W1563362496 @default.
- W2061768189 cites W1775749144 @default.
- W2061768189 cites W1806194750 @default.
- W2061768189 cites W1903873355 @default.
- W2061768189 cites W1951469402 @default.
- W2061768189 cites W1986728257 @default.
- W2061768189 cites W1994117763 @default.
- W2061768189 cites W1998592049 @default.
- W2061768189 cites W2005190479 @default.
- W2061768189 cites W2015670829 @default.
- W2061768189 cites W2019598918 @default.
- W2061768189 cites W2023284039 @default.
- W2061768189 cites W2041544891 @default.
- W2061768189 cites W2046645659 @default.
- W2061768189 cites W2060510291 @default.
- W2061768189 cites W2066300523 @default.
- W2061768189 cites W2336000290 @default.
- W2061768189 cites W4322574969 @default.
- W2061768189 doi "https://doi.org/10.1111/1523-1747.ep12500057" @default.
- W2061768189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7108267" @default.
- W2061768189 hasPublicationYear "1982" @default.
- W2061768189 type Work @default.
- W2061768189 sameAs 2061768189 @default.
- W2061768189 citedByCount "15" @default.
- W2061768189 countsByYear W20617681892013 @default.
- W2061768189 countsByYear W20617681892016 @default.
- W2061768189 crossrefType "journal-article" @default.
- W2061768189 hasAuthorship W2061768189A5003753703 @default.
- W2061768189 hasAuthorship W2061768189A5028792227 @default.
- W2061768189 hasAuthorship W2061768189A5076875729 @default.
- W2061768189 hasAuthorship W2061768189A5082425428 @default.
- W2061768189 hasBestOaLocation W20617681891 @default.
- W2061768189 hasConcept C181199279 @default.
- W2061768189 hasConcept C185592680 @default.
- W2061768189 hasConcept C203014093 @default.
- W2061768189 hasConcept C2779156968 @default.
- W2061768189 hasConcept C2780035454 @default.
- W2061768189 hasConcept C2780200183 @default.
- W2061768189 hasConcept C2780564577 @default.
- W2061768189 hasConcept C2780753045 @default.
- W2061768189 hasConcept C2780768313 @default.
- W2061768189 hasConcept C526171541 @default.
- W2061768189 hasConcept C55493867 @default.
- W2061768189 hasConcept C71924100 @default.
- W2061768189 hasConcept C86745063 @default.
- W2061768189 hasConcept C87644729 @default.
- W2061768189 hasConcept C89311334 @default.
- W2061768189 hasConcept C98274493 @default.
- W2061768189 hasConceptScore W2061768189C181199279 @default.
- W2061768189 hasConceptScore W2061768189C185592680 @default.
- W2061768189 hasConceptScore W2061768189C203014093 @default.
- W2061768189 hasConceptScore W2061768189C2779156968 @default.
- W2061768189 hasConceptScore W2061768189C2780035454 @default.
- W2061768189 hasConceptScore W2061768189C2780200183 @default.
- W2061768189 hasConceptScore W2061768189C2780564577 @default.
- W2061768189 hasConceptScore W2061768189C2780753045 @default.
- W2061768189 hasConceptScore W2061768189C2780768313 @default.
- W2061768189 hasConceptScore W2061768189C526171541 @default.
- W2061768189 hasConceptScore W2061768189C55493867 @default.
- W2061768189 hasConceptScore W2061768189C71924100 @default.
- W2061768189 hasConceptScore W2061768189C86745063 @default.
- W2061768189 hasConceptScore W2061768189C87644729 @default.
- W2061768189 hasConceptScore W2061768189C89311334 @default.
- W2061768189 hasConceptScore W2061768189C98274493 @default.
- W2061768189 hasIssue "3" @default.
- W2061768189 hasLocation W20617681891 @default.
- W2061768189 hasLocation W20617681892 @default.
- W2061768189 hasOpenAccess W2061768189 @default.
- W2061768189 hasPrimaryLocation W20617681891 @default.
- W2061768189 hasRelatedWork W1971567297 @default.
- W2061768189 hasRelatedWork W1980407312 @default.
- W2061768189 hasRelatedWork W1988026737 @default.
- W2061768189 hasRelatedWork W2061768189 @default.
- W2061768189 hasRelatedWork W2067772266 @default.
- W2061768189 hasRelatedWork W2117660567 @default.
- W2061768189 hasRelatedWork W2150438415 @default.
- W2061768189 hasRelatedWork W2405186864 @default.
- W2061768189 hasRelatedWork W2968871014 @default.
- W2061768189 hasRelatedWork W2094466373 @default.
- W2061768189 hasVolume "79" @default.
- W2061768189 isParatext "false" @default.
- W2061768189 isRetracted "false" @default.
- W2061768189 magId "2061768189" @default.
- W2061768189 workType "article" @default.