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• W2061774339 abstract "An 11-year-old boy with hypertension was suspected of having bilateral adrenal pheochromocytomas and hyperplasia. Molecular analysis of specific tumor suppressor genes and oncogenes excluded the familial syndromes, von Hippel-Lindau (VHL) disease and multiple endocrine neoplasia (MEN) type 2A. Further evaluation identified a unilateral adrenal pheochromocytoma with a VHL heterozygous somatic mutation (G695A) and loss of the maternal allele at 11p15.5-11p14 exclusively in the tumor tissue. Both reverse-transcriptase polymerase chain reaction and immunohistochemistry confirmed increased expression of IGF2 within the tumoral tissue, relative to a normal control adrenal gland. These results ruled out familial syndromes and suggested that the VHL mutation and the loss of maternal allele on chromosome 11 could have contributed to tumor development." @default.
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• W2061774339 date "2001-02-01" @default.
• W2061774339 modified "2023-10-03" @default.
• W2061774339 title "Molecular characterization of a pediatric pheochromocytoma with suspected bilateral disease" @default.
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• W2061774339 doi "https://doi.org/10.1067/mpd.2001.111316" @default.
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