FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061778700> ?p ?o ?g. }

• W2061778700 abstract "Developmental changes in 5alpha-pregnan-3alpha-ol-20-one (allopregnanolone; 5alpha-3alpha-P) potentiation of muscimol and benzodiazepine binding to the GABAA receptor were studied in the guinea pig cerebral cortex at three prenatal ages (gestational day (GD) 40, GD 50, GD 62), and three postnatal ages (postnatal day (PD) 11, PD 21, PD 61) (term, about GD 68). The number and affinity of [3H]flunitrazepam binding sites, and 5alpha-3alpha-P potentiation of [3H]muscimol and [3H]flunitrazepam binding to the GABAA receptor were determined at each age. There was no age effect on the affinity (Kd) for [3H]flunitrazepam. However, the number (Bmax) of [3H]flunitrazepam binding sites doubled between GD 40 and GD 62, and then declined slightly to reach adult levels by PD 11. 5alpha-3alpha-P produced a concentration-dependent potentiation of [3H]muscimol and [3H]flunitrazepam binding at each developmental age examined. The potency (high-affinity) for 5alpha-3alpha-P potentiation of both [3H]muscimol and [3H]flunitrazepam binding was lowest at GD 40, and increased to adult levels by GD 62. In contrast, the efficacy for 5alpha-3alpha-P potentiation of both [3H]muscimol and [3H]flunitrazepam binding was greatest at GD 40, and decreased to adult levels between GD 50 and GD 62. The percentage of high-affinity zolpidem binding sites increased in an age-dependent manner from 34.2+/-2.2% at GD 40, to reach adult levels by GD 62 (59. 4+/-2.5%). These data suggest that 5alpha-3alpha-P can modulate GABAA receptors in the immature cerebral cortex, and that changes in 5alpha-3alpha-P action are temporally related to changes in GABAA receptor benzodiazepine pharmacology late in gestation in the guinea pig." @default.
• W2061778700 created "2016-06-24" @default.
• W2061778700 creator A5019429958 @default.
• W2061778700 creator A5033280558 @default.
• W2061778700 creator A5087502351 @default.
• W2061778700 date "1999-03-01" @default.
• W2061778700 modified "2023-10-14" @default.
• W2061778700 title "Neurosteroid modulation of the GABAA receptor in the developing guinea pig cerebral cortex" @default.
• W2061778700 cites W1574239291 @default.
• W2061778700 cites W1599121574 @default.
• W2061778700 cites W1604333472 @default.
• W2061778700 cites W1794897677 @default.
• W2061778700 cites W1877334982 @default.
• W2061778700 cites W1886356107 @default.
• W2061778700 cites W1952984479 @default.
• W2061778700 cites W1967229232 @default.
• W2061778700 cites W1972995375 @default.
• W2061778700 cites W1976496331 @default.
• W2061778700 cites W1988405118 @default.
• W2061778700 cites W1990256437 @default.
• W2061778700 cites W1992735831 @default.
• W2061778700 cites W1994924064 @default.
• W2061778700 cites W1995744884 @default.
• W2061778700 cites W1998765262 @default.
• W2061778700 cites W2001605191 @default.
• W2061778700 cites W2004010919 @default.
• W2061778700 cites W2012152879 @default.
• W2061778700 cites W2017177695 @default.
• W2061778700 cites W2024344189 @default.
• W2061778700 cites W2026320973 @default.
• W2061778700 cites W2027606344 @default.
• W2061778700 cites W2035441653 @default.
• W2061778700 cites W2038134987 @default.
• W2061778700 cites W2043045309 @default.
• W2061778700 cites W2051585413 @default.
• W2061778700 cites W2058404259 @default.
• W2061778700 cites W2059318434 @default.
• W2061778700 cites W2060674315 @default.
• W2061778700 cites W2064118544 @default.
• W2061778700 cites W2075405696 @default.
• W2061778700 cites W2077207465 @default.
• W2061778700 cites W2077468380 @default.
• W2061778700 cites W2080131125 @default.
• W2061778700 cites W2083447043 @default.
• W2061778700 cites W2083852352 @default.
• W2061778700 cites W2108262338 @default.
• W2061778700 cites W2110722854 @default.
• W2061778700 cites W2187721313 @default.
• W2061778700 cites W2291712389 @default.
• W2061778700 cites W2405577466 @default.
• W2061778700 cites W2410053025 @default.
• W2061778700 cites W2415011195 @default.
• W2061778700 doi "https://doi.org/10.1016/s0165-3806(98)00185-0" @default.
• W2061778700 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10064870" @default.
• W2061778700 hasPublicationYear "1999" @default.
• W2061778700 type Work @default.
• W2061778700 sameAs 2061778700 @default.
• W2061778700 citedByCount "12" @default.
• W2061778700 countsByYear W20617787002012 @default.
• W2061778700 countsByYear W20617787002014 @default.
• W2061778700 crossrefType "journal-article" @default.
• W2061778700 hasAuthorship W2061778700A5019429958 @default.
• W2061778700 hasAuthorship W2061778700A5033280558 @default.
• W2061778700 hasAuthorship W2061778700A5087502351 @default.
• W2061778700 hasConcept C126322002 @default.
• W2061778700 hasConcept C134018914 @default.
• W2061778700 hasConcept C168258287 @default.
• W2061778700 hasConcept C170493617 @default.
• W2061778700 hasConcept C185592680 @default.
• W2061778700 hasConcept C25274449 @default.
• W2061778700 hasConcept C2778338918 @default.
• W2061778700 hasConcept C2779188335 @default.
• W2061778700 hasConcept C2781442855 @default.
• W2061778700 hasConcept C44796713 @default.
• W2061778700 hasConcept C71924100 @default.
• W2061778700 hasConcept C86803240 @default.
• W2061778700 hasConceptScore W2061778700C126322002 @default.
• W2061778700 hasConceptScore W2061778700C134018914 @default.
• W2061778700 hasConceptScore W2061778700C168258287 @default.
• W2061778700 hasConceptScore W2061778700C170493617 @default.
• W2061778700 hasConceptScore W2061778700C185592680 @default.
• W2061778700 hasConceptScore W2061778700C25274449 @default.
• W2061778700 hasConceptScore W2061778700C2778338918 @default.
• W2061778700 hasConceptScore W2061778700C2779188335 @default.
• W2061778700 hasConceptScore W2061778700C2781442855 @default.
• W2061778700 hasConceptScore W2061778700C44796713 @default.
• W2061778700 hasConceptScore W2061778700C71924100 @default.
• W2061778700 hasConceptScore W2061778700C86803240 @default.
• W2061778700 hasLocation W20617787001 @default.
• W2061778700 hasLocation W20617787002 @default.
• W2061778700 hasOpenAccess W2061778700 @default.
• W2061778700 hasPrimaryLocation W20617787001 @default.
• W2061778700 hasRelatedWork W1790534678 @default.
• W2061778700 hasRelatedWork W1974839934 @default.
• W2061778700 hasRelatedWork W1991648062 @default.
• W2061778700 hasRelatedWork W1995626255 @default.
• W2061778700 hasRelatedWork W2050089594 @default.
• W2061778700 hasRelatedWork W2059623354 @default.
• W2061778700 hasRelatedWork W2061778700 @default.
• W2061778700 hasRelatedWork W2065089135 @default.

• next