FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061781722> ?p ?o ?g. }

• W2061781722 endingPage "???" @default.
• W2061781722 startingPage "070607050851003" @default.
• W2061781722 abstract "Context A GHR-exon 3 polymorphism has been reported to influence the growth response to hGH therapy in short stature children. None of these studies provided data on IGF-1 generation test. Objective To evaluate the influence of the GHR-exon 3 polymorphism on the generation test in children with idiopathic short stature (ISS). Design and patients A total of 45 prepubertal ISS children were submitted to IGF-1 and IGFBP-3 generation test (4 days of hGH 33 µg/kg/day). Children were genotyped for GHR-exon 3: full-length (fl) and exon 3-deleted (d3) alleles. Measurements IGF-1 and IGFBP-3 increment as absolute values and standard deviation scores (SDS). Results Basal clinical and laboratory data were similar among patients with different genotypes (fl/fl vs. fl/d3 or d3/d3). All patients presented IGF-1 increase ≥ 15 µg/l at generation test. Children with GHRd3 allele, as a group, presented a statistically significant higher IGF-1 SDS increase at generation test than children homozygous for GHRfl allele (1·0 ranging from 0·1 to 3·7 for fl/fl vs. 1·2 ranging from 0·3 to 4·4 for fl/d3 and d3/d3; P = 0·037). Multiple linear regression found a positive association between increase in IGF-1 SDS with chronological age (P = 0·007) and GHR genotype (P = 0·027), which together explain 24% of the variability of IGF-1 SDS increment at generation test. There was no difference in IGFBP-3 generation test between the two genotype groups. Conclusion This study demonstrates that ISS children carrying the GHRd3 allele, as a group, present a slightly higher GH sensitivity regarding short-term IGF-1 generation during hGH stimulus than children homozygous for GHRfl allele." @default.
• W2061781722 created "2016-06-24" @default.
• W2061781722 creator A5033122740 @default.
• W2061781722 creator A5048394640 @default.
• W2061781722 creator A5050232295 @default.
• W2061781722 creator A5056408960 @default.
• W2061781722 creator A5070035952 @default.
• W2061781722 creator A5072532547 @default.
• W2061781722 date "2007-06-07" @default.
• W2061781722 modified "2023-10-10" @default.
• W2061781722 title "Exon 3-deleted genotype of growth hormone receptor (GHRd3) positively influences IGF-1 increase at generation test in children with idiopathic short stature" @default.
• W2061781722 cites W1974748523 @default.
• W2061781722 cites W1980992626 @default.
• W2061781722 cites W1987050653 @default.
• W2061781722 cites W1988159556 @default.
• W2061781722 cites W1988951741 @default.
• W2061781722 cites W1989907280 @default.
• W2061781722 cites W1997522702 @default.
• W2061781722 cites W1998490378 @default.
• W2061781722 cites W2004444277 @default.
• W2061781722 cites W2012102363 @default.
• W2061781722 cites W2037053329 @default.
• W2061781722 cites W2040178108 @default.
• W2061781722 cites W2042394833 @default.
• W2061781722 cites W2045841831 @default.
• W2061781722 cites W2050853712 @default.
• W2061781722 cites W2053418734 @default.
• W2061781722 cites W2075509369 @default.
• W2061781722 cites W2075598023 @default.
• W2061781722 cites W2077122859 @default.
• W2061781722 cites W2091646210 @default.
• W2061781722 cites W2152469005 @default.
• W2061781722 cites W2158823568 @default.
• W2061781722 cites W4245970481 @default.
• W2061781722 doi "https://doi.org/10.1111/j.1365-2265.2007.02915.x" @default.
• W2061781722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17555512" @default.
• W2061781722 hasPublicationYear "2007" @default.
• W2061781722 type Work @default.
• W2061781722 sameAs 2061781722 @default.
• W2061781722 citedByCount "13" @default.
• W2061781722 countsByYear W20617817222015 @default.
• W2061781722 countsByYear W20617817222016 @default.
• W2061781722 countsByYear W20617817222022 @default.
• W2061781722 crossrefType "journal-article" @default.
• W2061781722 hasAuthorship W2061781722A5033122740 @default.
• W2061781722 hasAuthorship W2061781722A5048394640 @default.
• W2061781722 hasAuthorship W2061781722A5050232295 @default.
• W2061781722 hasAuthorship W2061781722A5056408960 @default.
• W2061781722 hasAuthorship W2061781722A5070035952 @default.
• W2061781722 hasAuthorship W2061781722A5072532547 @default.
• W2061781722 hasConcept C104317684 @default.
• W2061781722 hasConcept C113675107 @default.
• W2061781722 hasConcept C126322002 @default.
• W2061781722 hasConcept C134018914 @default.
• W2061781722 hasConcept C135763542 @default.
• W2061781722 hasConcept C149737253 @default.
• W2061781722 hasConcept C151730666 @default.
• W2061781722 hasConcept C180754005 @default.
• W2061781722 hasConcept C2777871287 @default.
• W2061781722 hasConcept C2778024521 @default.
• W2061781722 hasConcept C2778754045 @default.
• W2061781722 hasConcept C2779306644 @default.
• W2061781722 hasConcept C2779343474 @default.
• W2061781722 hasConcept C2984496839 @default.
• W2061781722 hasConcept C36823959 @default.
• W2061781722 hasConcept C54355233 @default.
• W2061781722 hasConcept C71315377 @default.
• W2061781722 hasConcept C71924100 @default.
• W2061781722 hasConcept C86803240 @default.
• W2061781722 hasConceptScore W2061781722C104317684 @default.
• W2061781722 hasConceptScore W2061781722C113675107 @default.
• W2061781722 hasConceptScore W2061781722C126322002 @default.
• W2061781722 hasConceptScore W2061781722C134018914 @default.
• W2061781722 hasConceptScore W2061781722C135763542 @default.
• W2061781722 hasConceptScore W2061781722C149737253 @default.
• W2061781722 hasConceptScore W2061781722C151730666 @default.
• W2061781722 hasConceptScore W2061781722C180754005 @default.
• W2061781722 hasConceptScore W2061781722C2777871287 @default.
• W2061781722 hasConceptScore W2061781722C2778024521 @default.
• W2061781722 hasConceptScore W2061781722C2778754045 @default.
• W2061781722 hasConceptScore W2061781722C2779306644 @default.
• W2061781722 hasConceptScore W2061781722C2779343474 @default.
• W2061781722 hasConceptScore W2061781722C2984496839 @default.
• W2061781722 hasConceptScore W2061781722C36823959 @default.
• W2061781722 hasConceptScore W2061781722C54355233 @default.
• W2061781722 hasConceptScore W2061781722C71315377 @default.
• W2061781722 hasConceptScore W2061781722C71924100 @default.
• W2061781722 hasConceptScore W2061781722C86803240 @default.
• W2061781722 hasIssue "0" @default.
• W2061781722 hasLocation W20617817221 @default.
• W2061781722 hasLocation W20617817222 @default.
• W2061781722 hasOpenAccess W2061781722 @default.
• W2061781722 hasPrimaryLocation W20617817221 @default.
• W2061781722 hasRelatedWork W2009766761 @default.
• W2061781722 hasRelatedWork W2027062663 @default.
• W2061781722 hasRelatedWork W2030010168 @default.
• W2061781722 hasRelatedWork W2064991548 @default.
• W2061781722 hasRelatedWork W2105710561 @default.

• next