FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061782882> ?p ?o ?g. }

• W2061782882 endingPage "325" @default.
• W2061782882 startingPage "317" @default.
• W2061782882 abstract "3-Nitropropionic acid (3-NP) induces hearing loss by impairing mitochondrial energy generation. Geranylgeranylacetone (GGA) is known to protect the cochlea from various injuries. The present study was designed to investigate the protective effect of GGA against acute 3-NP-induced damage to the cochlear mitochondria. Female Hartley guinea pigs were divided into 4 groups. The 3-NP vehicle was injected to control animals and in animals receiving GGA alone, only GGA was administered for 7 days. 3-NP (500 mM, 4 μl) was administered with (animals receiving both GGA and 3-NP) or without (animals receiving 3-NP alone) GGA pretreatment (800 mg/kg, 7 days). The auditory brainstem response (ABR) was recorded at click and at 8, 16 and 32 kHz before and after injection, respectively. After cochlear harvest, hematoxylin/eosin staining and immunohistochemistry for anti-HSP70 antibody were done. 3-NP exposure resulted in elevated ABR thresholds that exceeded the maximum recording limit, while GGA pretreatment before 3-NP exposure led to a significant decrease in hearing threshold shift. Histological analysis of above former group revealed loss of type II fibrocytes in the spiral ligament, hair cells in the organ of Corti, stellate fibrocytes in the spiral limbus and spiral ganglion cells, while in above latter group, these cells were preserved. Control animals revealed weak HSP70 expression in the nuclei of some supporting cells (pillar cells, Deiters’ cells and Hensen's cells) and interdental cells. Animals receiving GGA alone showed strong HSP70 expression in the same area as in control animals, while animals receiving both GGA and 3-NP demonstrated slightly decreased HSP70 expression in that area. These results suggest that GGA may protect the cochlea against acute injury resulting from mitochondrial dysfunction." @default.
• W2061782882 created "2016-06-24" @default.
• W2061782882 creator A5005572021 @default.
• W2061782882 creator A5010202527 @default.
• W2061782882 creator A5011861620 @default.
• W2061782882 creator A5025153310 @default.
• W2061782882 creator A5032613665 @default.
• W2061782882 creator A5040810589 @default.
• W2061782882 creator A5044912860 @default.
• W2061782882 creator A5046555120 @default.
• W2061782882 creator A5055496629 @default.
• W2061782882 date "2010-06-01" @default.
• W2061782882 modified "2023-09-27" @default.
• W2061782882 title "Geranylgeranylacetone ameliorates acute cochlear damage caused by 3-nitropropionic acid" @default.
• W2061782882 cites W1563847798 @default.
• W2061782882 cites W1694452890 @default.
• W2061782882 cites W1979120081 @default.
• W2061782882 cites W1980031124 @default.
• W2061782882 cites W1984431577 @default.
• W2061782882 cites W1990549525 @default.
• W2061782882 cites W1993275036 @default.
• W2061782882 cites W1993643311 @default.
• W2061782882 cites W1994741564 @default.
• W2061782882 cites W1995249229 @default.
• W2061782882 cites W2046639009 @default.
• W2061782882 cites W2062359737 @default.
• W2061782882 cites W2067067725 @default.
• W2061782882 cites W2070622971 @default.
• W2061782882 cites W2073979475 @default.
• W2061782882 cites W2075403799 @default.
• W2061782882 cites W2077440005 @default.
• W2061782882 cites W2084736894 @default.
• W2061782882 cites W2087004164 @default.
• W2061782882 cites W2087378033 @default.
• W2061782882 cites W2088662719 @default.
• W2061782882 cites W2089984249 @default.
• W2061782882 cites W2093356787 @default.
• W2061782882 cites W2101311674 @default.
• W2061782882 cites W2105467535 @default.
• W2061782882 cites W2107789276 @default.
• W2061782882 cites W2108972125 @default.
• W2061782882 cites W2112696881 @default.
• W2061782882 cites W2114108920 @default.
• W2061782882 cites W2134247937 @default.
• W2061782882 cites W2164340078 @default.
• W2061782882 cites W2168601768 @default.
• W2061782882 doi "https://doi.org/10.1016/j.neuro.2010.03.001" @default.
• W2061782882 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20226206" @default.
• W2061782882 hasPublicationYear "2010" @default.
• W2061782882 type Work @default.
• W2061782882 sameAs 2061782882 @default.
• W2061782882 citedByCount "9" @default.
• W2061782882 countsByYear W20617828822012 @default.
• W2061782882 countsByYear W20617828822013 @default.
• W2061782882 countsByYear W20617828822017 @default.
• W2061782882 countsByYear W20617828822019 @default.
• W2061782882 countsByYear W20617828822020 @default.
• W2061782882 crossrefType "journal-article" @default.
• W2061782882 hasAuthorship W2061782882A5005572021 @default.
• W2061782882 hasAuthorship W2061782882A5010202527 @default.
• W2061782882 hasAuthorship W2061782882A5011861620 @default.
• W2061782882 hasAuthorship W2061782882A5025153310 @default.
• W2061782882 hasAuthorship W2061782882A5032613665 @default.
• W2061782882 hasAuthorship W2061782882A5040810589 @default.
• W2061782882 hasAuthorship W2061782882A5044912860 @default.
• W2061782882 hasAuthorship W2061782882A5046555120 @default.
• W2061782882 hasAuthorship W2061782882A5055496629 @default.
• W2061782882 hasConcept C105702510 @default.
• W2061782882 hasConcept C125473707 @default.
• W2061782882 hasConcept C126322002 @default.
• W2061782882 hasConcept C134018914 @default.
• W2061782882 hasConcept C142724271 @default.
• W2061782882 hasConcept C16685009 @default.
• W2061782882 hasConcept C185592680 @default.
• W2061782882 hasConcept C204232928 @default.
• W2061782882 hasConcept C2779152698 @default.
• W2061782882 hasConcept C2780130748 @default.
• W2061782882 hasConcept C2780408329 @default.
• W2061782882 hasConcept C2780493683 @default.
• W2061782882 hasConcept C2780659331 @default.
• W2061782882 hasConcept C43791021 @default.
• W2061782882 hasConcept C548259974 @default.
• W2061782882 hasConcept C71924100 @default.
• W2061782882 hasConcept C86803240 @default.
• W2061782882 hasConceptScore W2061782882C105702510 @default.
• W2061782882 hasConceptScore W2061782882C125473707 @default.
• W2061782882 hasConceptScore W2061782882C126322002 @default.
• W2061782882 hasConceptScore W2061782882C134018914 @default.
• W2061782882 hasConceptScore W2061782882C142724271 @default.
• W2061782882 hasConceptScore W2061782882C16685009 @default.
• W2061782882 hasConceptScore W2061782882C185592680 @default.
• W2061782882 hasConceptScore W2061782882C204232928 @default.
• W2061782882 hasConceptScore W2061782882C2779152698 @default.
• W2061782882 hasConceptScore W2061782882C2780130748 @default.
• W2061782882 hasConceptScore W2061782882C2780408329 @default.
• W2061782882 hasConceptScore W2061782882C2780493683 @default.
• W2061782882 hasConceptScore W2061782882C2780659331 @default.
• W2061782882 hasConceptScore W2061782882C43791021 @default.

• next