Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061787025> ?p ?o ?g. }
- W2061787025 endingPage "427" @default.
- W2061787025 startingPage "418" @default.
- W2061787025 abstract "Reactive oxygen species and oxidative stress are involved in quinolinic acid (QUIN)-induced neurotoxicity. QUIN, a N-methyl-D-aspartate receptor (NMDAr) agonist and prooxidant molecule, produces NMDAr overactivation, excitotoxic events, and direct reactive oxygen species formation. Copper is an essential metal exhibiting both modulatory effects on neuronal excitatory activity and antioxidant properties. To investigate whether this metal is able to counteract the neurotoxic and oxidative actions of QUIN, we administered copper (as CuSO4) intraperitoneally to rats (2.5, 5.0, 7.5, and 10.0 mg/kg) 30 min before the striatal infusion of 1 μl of QUIN (240 nmol). A 5.0 mg/kg CuSO4 dose significantly increased the copper content in the striatum, reduced the neurotoxicity measured both as circling behavior and striatal γ-aminobutyric acid (GABA) depletion, and blocked the oxidative injury evaluated as striatal lipid peroxidation (LP). In addition, copper reduced the QUIN-induced decreased striatal activity of Cu,Zn-dependent superoxide dismutase, and increased the ferroxidase activity of ceruloplasmin in cerebrospinal fluid from QUIN-treated rats. However, copper also produced significant increases of plasma lactate dehydrogenase activity and mortality at the highest doses employed (7.5 and 10.0 mg/kg). These results show that at low doses, copper exerts a protective effect on in vivo QUIN neurotoxicity." @default.
- W2061787025 created "2016-06-24" @default.
- W2061787025 creator A5001694539 @default.
- W2061787025 creator A5005501707 @default.
- W2061787025 creator A5011957243 @default.
- W2061787025 creator A5014832855 @default.
- W2061787025 creator A5016993423 @default.
- W2061787025 creator A5032377993 @default.
- W2061787025 creator A5032582046 @default.
- W2061787025 creator A5062288542 @default.
- W2061787025 creator A5071169613 @default.
- W2061787025 creator A5079462703 @default.
- W2061787025 creator A5091442700 @default.
- W2061787025 date "2003-08-01" @default.
- W2061787025 modified "2023-10-18" @default.
- W2061787025 title "Copper blocks quinolinic acid neurotoxicity in rats: contribution of antioxidant systems" @default.
- W2061787025 cites W1500494533 @default.
- W2061787025 cites W1542526845 @default.
- W2061787025 cites W1543530330 @default.
- W2061787025 cites W155239536 @default.
- W2061787025 cites W1597969908 @default.
- W2061787025 cites W1775749144 @default.
- W2061787025 cites W1968623439 @default.
- W2061787025 cites W1976079618 @default.
- W2061787025 cites W1981234599 @default.
- W2061787025 cites W1982021911 @default.
- W2061787025 cites W1983985990 @default.
- W2061787025 cites W1984475565 @default.
- W2061787025 cites W1988316455 @default.
- W2061787025 cites W1989971741 @default.
- W2061787025 cites W1994611803 @default.
- W2061787025 cites W1999018613 @default.
- W2061787025 cites W1999059174 @default.
- W2061787025 cites W2000248133 @default.
- W2061787025 cites W2002763309 @default.
- W2061787025 cites W2006760569 @default.
- W2061787025 cites W2009372142 @default.
- W2061787025 cites W2010145371 @default.
- W2061787025 cites W2013245846 @default.
- W2061787025 cites W2016293448 @default.
- W2061787025 cites W2019072693 @default.
- W2061787025 cites W2020385832 @default.
- W2061787025 cites W2020543394 @default.
- W2061787025 cites W2029956630 @default.
- W2061787025 cites W2038720481 @default.
- W2061787025 cites W2050207924 @default.
- W2061787025 cites W2051353156 @default.
- W2061787025 cites W2054130988 @default.
- W2061787025 cites W2055690153 @default.
- W2061787025 cites W2057019886 @default.
- W2061787025 cites W2061611794 @default.
- W2061787025 cites W2062889027 @default.
- W2061787025 cites W2064701360 @default.
- W2061787025 cites W2066763924 @default.
- W2061787025 cites W2077851512 @default.
- W2061787025 cites W2078896967 @default.
- W2061787025 cites W2079402579 @default.
- W2061787025 cites W2080730316 @default.
- W2061787025 cites W2083377642 @default.
- W2061787025 cites W2083949851 @default.
- W2061787025 cites W2084990956 @default.
- W2061787025 cites W2107113836 @default.
- W2061787025 cites W2109516103 @default.
- W2061787025 cites W2113919453 @default.
- W2061787025 cites W2277252157 @default.
- W2061787025 cites W2330712602 @default.
- W2061787025 cites W2743736005 @default.
- W2061787025 cites W324236819 @default.
- W2061787025 doi "https://doi.org/10.1016/s0891-5849(03)00317-4" @default.
- W2061787025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12899943" @default.
- W2061787025 hasPublicationYear "2003" @default.
- W2061787025 type Work @default.
- W2061787025 sameAs 2061787025 @default.
- W2061787025 citedByCount "42" @default.
- W2061787025 countsByYear W20617870252012 @default.
- W2061787025 countsByYear W20617870252013 @default.
- W2061787025 countsByYear W20617870252014 @default.
- W2061787025 countsByYear W20617870252016 @default.
- W2061787025 countsByYear W20617870252017 @default.
- W2061787025 countsByYear W20617870252018 @default.
- W2061787025 countsByYear W20617870252019 @default.
- W2061787025 countsByYear W20617870252021 @default.
- W2061787025 countsByYear W20617870252022 @default.
- W2061787025 crossrefType "journal-article" @default.
- W2061787025 hasAuthorship W2061787025A5001694539 @default.
- W2061787025 hasAuthorship W2061787025A5005501707 @default.
- W2061787025 hasAuthorship W2061787025A5011957243 @default.
- W2061787025 hasAuthorship W2061787025A5014832855 @default.
- W2061787025 hasAuthorship W2061787025A5016993423 @default.
- W2061787025 hasAuthorship W2061787025A5032377993 @default.
- W2061787025 hasAuthorship W2061787025A5032582046 @default.
- W2061787025 hasAuthorship W2061787025A5062288542 @default.
- W2061787025 hasAuthorship W2061787025A5071169613 @default.
- W2061787025 hasAuthorship W2061787025A5079462703 @default.
- W2061787025 hasAuthorship W2061787025A5091442700 @default.
- W2061787025 hasConcept C170493617 @default.
- W2061787025 hasConcept C178790620 @default.
- W2061787025 hasConcept C181199279 @default.