FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061796256> ?p ?o ?g. }

• W2061796256 endingPage "466" @default.
• W2061796256 startingPage "458" @default.
• W2061796256 abstract "Nasopharyngeal carcinoma (NPC) is predominantly of the undifferentiated histological subtype. Histological differentiation is of limited prognostic significance in NPC. Recent studies have suggested that downregulation of the cadherin-catenin cell adhesion complex may play a crucial role in the initial stage of cancer invasion and metastasis and is associated with poor prognosis in human cancers. Expression of E-cadherin has not been reported previously in NPC, and its prognostic value in NPC is unknown. The purpose of this study was to examine the expression pattern of E-cadherin and its associated partner, β-catenin, in NPC and their possible applications as prognostic markers to predict the clinical outcome of NPC. Expression of the E-cadherin and β-catenin was examined by immunohistochemical methods in 74 cases of primary NPC and 17 of their corresponding lymph node metastases. Normal nasopharyngeal epithelium showed strong and homogeneous immunocytochemical staining of E-cadherin and β-catenin at the cell membranes and intercellular junctions. In contrast, primary NPC showed variable and heterogeneous staining patterns of E-cadherin and β-catenin. Loss of membranous E-cadherin expression was significantly associated with advanced stages of diseases (P < .001). Eighty percent to ninety percent of NPC in stages IV and V (Ho's staging), respectively, showed a reduced (<35%) membranous staining of E-cadherin compared with normal nasopharyngeal epithelium. Expression of β-catenin also was downregulated in advanced NPC. Ninety percent to one hundred percent of NPC in stages IV and V (Ho's staging) expressed a reduction (<35%) of immunocytochemical staining of β-catenin. The expression pattern of β-catenin staining was strongly associated with the expression of E-cadherin (P < .001). Unlike E-cadherin, nuclear staining of β-catenin expression was observed in some of the primary NPC and lymph node metastasis. Reduced expression of E-cadherin and β-catenin expression was associated with a shorter survival of NPC patients (P < .001). In advanced NPC patients (stages IV and V), a significant difference in survival was observed in tumors with higher or lower levels of E-cadherin expression (P = .0224, log-rank test). These observations suggests that expression of E-cadherin and β-catenin may have prognostic values in NPC patients." @default.
• W2061796256 created "2016-06-24" @default.
• W2061796256 creator A5004863047 @default.
• W2061796256 creator A5024405409 @default.
• W2061796256 creator A5029067036 @default.
• W2061796256 creator A5069311189 @default.
• W2061796256 creator A5086159719 @default.
• W2061796256 creator A5091453336 @default.
• W2061796256 date "1999-04-01" @default.
• W2061796256 modified "2023-10-17" @default.
• W2061796256 title "Downregulation and abnormal expression of E-cadherin and β-catenin in nasopharyngeal carcinoma: Close association with advanced disease stage and lymph node metastasis" @default.
• W2061796256 cites W2016291097 @default.
• W2061796256 cites W2038617171 @default.
• W2061796256 cites W2041043194 @default.
• W2061796256 cites W2041386436 @default.
• W2061796256 cites W2052018833 @default.
• W2061796256 cites W2061778202 @default.
• W2061796256 cites W2075596154 @default.
• W2061796256 cites W2076530204 @default.
• W2061796256 cites W2108360007 @default.
• W2061796256 cites W2129775855 @default.
• W2061796256 cites W2144300167 @default.
• W2061796256 doi "https://doi.org/10.1016/s0046-8177(99)90123-5" @default.
• W2061796256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10208469" @default.
• W2061796256 hasPublicationYear "1999" @default.
• W2061796256 type Work @default.
• W2061796256 sameAs 2061796256 @default.
• W2061796256 citedByCount "136" @default.
• W2061796256 countsByYear W20617962562012 @default.
• W2061796256 countsByYear W20617962562013 @default.
• W2061796256 countsByYear W20617962562014 @default.
• W2061796256 countsByYear W20617962562015 @default.
• W2061796256 countsByYear W20617962562016 @default.
• W2061796256 countsByYear W20617962562017 @default.
• W2061796256 countsByYear W20617962562018 @default.
• W2061796256 countsByYear W20617962562020 @default.
• W2061796256 countsByYear W20617962562021 @default.
• W2061796256 countsByYear W20617962562022 @default.
• W2061796256 countsByYear W20617962562023 @default.
• W2061796256 crossrefType "journal-article" @default.
• W2061796256 hasAuthorship W2061796256A5004863047 @default.
• W2061796256 hasAuthorship W2061796256A5024405409 @default.
• W2061796256 hasAuthorship W2061796256A5029067036 @default.
• W2061796256 hasAuthorship W2061796256A5069311189 @default.
• W2061796256 hasAuthorship W2061796256A5086159719 @default.
• W2061796256 hasAuthorship W2061796256A5091453336 @default.
• W2061796256 hasConcept C104317684 @default.
• W2061796256 hasConcept C121608353 @default.
• W2061796256 hasConcept C126322002 @default.
• W2061796256 hasConcept C127561419 @default.
• W2061796256 hasConcept C137620995 @default.
• W2061796256 hasConcept C142724271 @default.
• W2061796256 hasConcept C146357865 @default.
• W2061796256 hasConcept C1491633281 @default.
• W2061796256 hasConcept C149402561 @default.
• W2061796256 hasConcept C151730666 @default.
• W2061796256 hasConcept C204232928 @default.
• W2061796256 hasConcept C2777546739 @default.
• W2061796256 hasConcept C2778997737 @default.
• W2061796256 hasConcept C2779013556 @default.
• W2061796256 hasConcept C2780849966 @default.
• W2061796256 hasConcept C30145163 @default.
• W2061796256 hasConcept C509974204 @default.
• W2061796256 hasConcept C54355233 @default.
• W2061796256 hasConcept C55493867 @default.
• W2061796256 hasConcept C62478195 @default.
• W2061796256 hasConcept C71924100 @default.
• W2061796256 hasConcept C74864618 @default.
• W2061796256 hasConcept C86803240 @default.
• W2061796256 hasConceptScore W2061796256C104317684 @default.
• W2061796256 hasConceptScore W2061796256C121608353 @default.
• W2061796256 hasConceptScore W2061796256C126322002 @default.
• W2061796256 hasConceptScore W2061796256C127561419 @default.
• W2061796256 hasConceptScore W2061796256C137620995 @default.
• W2061796256 hasConceptScore W2061796256C142724271 @default.
• W2061796256 hasConceptScore W2061796256C146357865 @default.
• W2061796256 hasConceptScore W2061796256C1491633281 @default.
• W2061796256 hasConceptScore W2061796256C149402561 @default.
• W2061796256 hasConceptScore W2061796256C151730666 @default.
• W2061796256 hasConceptScore W2061796256C204232928 @default.
• W2061796256 hasConceptScore W2061796256C2777546739 @default.
• W2061796256 hasConceptScore W2061796256C2778997737 @default.
• W2061796256 hasConceptScore W2061796256C2779013556 @default.
• W2061796256 hasConceptScore W2061796256C2780849966 @default.
• W2061796256 hasConceptScore W2061796256C30145163 @default.
• W2061796256 hasConceptScore W2061796256C509974204 @default.
• W2061796256 hasConceptScore W2061796256C54355233 @default.
• W2061796256 hasConceptScore W2061796256C55493867 @default.
• W2061796256 hasConceptScore W2061796256C62478195 @default.
• W2061796256 hasConceptScore W2061796256C71924100 @default.
• W2061796256 hasConceptScore W2061796256C74864618 @default.
• W2061796256 hasConceptScore W2061796256C86803240 @default.
• W2061796256 hasIssue "4" @default.
• W2061796256 hasLocation W20617962561 @default.
• W2061796256 hasLocation W20617962562 @default.
• W2061796256 hasOpenAccess W2061796256 @default.
• W2061796256 hasPrimaryLocation W20617962561 @default.
• W2061796256 hasRelatedWork W1513677097 @default.

• next