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- W2061796746 abstract "We tested Tankyrase-1 mRNA expression in colon cancer patients to evaluate the prognostic role of this parameter by real-time RT-PCR in a retrospective group of 82 unselected patients with colon cancer. Paired cancer and corresponding not affected tissues were used. Laser-assisted microdissection was used to measure Tankyrase-1 mRNA in homogeneous cancer cell populations and in normal colon epithelium of the same patients. Tankyrase-1 mRNA in colon cancers, as a mean, was significantly higher than in paired not affected tissues (p<0.0001), but its level correlates inversely with a cancer progression stage. Survival analysis indicated that lower Tankyrase-1 mRNA expression in colon cancers was significantly associated to reduced patient survival (p=0.019) and disease-free interval (p=0.035), confirmed also in a multi-variate analysis." @default.
- W2061796746 created "2016-06-24" @default.
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- W2061796746 date "2006-12-01" @default.
- W2061796746 modified "2023-09-27" @default.
- W2061796746 title "Distribution of Tankyrase-1 mRNA expression in colon cancer and its prospective correlation with progression stage" @default.
- W2061796746 doi "https://doi.org/10.3892/or.16.6.1261" @default.
- W2061796746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17089047" @default.
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