FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061818013> ?p ?o ?g. }

• W2061818013 endingPage "e1001019" @default.
• W2061818013 startingPage "e1001019" @default.
• W2061818013 abstract "The anterior visceral endoderm (AVE), a signalling centre within the simple epithelium of the visceral endoderm (VE), is required for anterior-posterior axis specification in the mouse embryo. AVE cells migrate directionally within the VE, thereby properly positioning the future anterior of the embryo and orientating the primary body axis. AVE cells consistently come to an abrupt stop at the border between the anterior epiblast and extra-embryonic ectoderm, which represents an end-point to their proximal migration. Little is known about the underlying basis for this barrier and how surrounding cells in the VE respond to or influence AVE migration. We use high-resolution 3D reconstructions of protein localisation patterns and time-lapse microscopy to show that AVE cells move by exchanging neighbours within an intact epithelium. Cell movement and mixing is restricted to the VE overlying the epiblast, characterised by the enrichment of Dishevelled-2 (Dvl2) to the lateral plasma membrane, a hallmark of Planar Cell Polarity (PCP) signalling. AVE cells halt upon reaching the adjoining region of VE overlying the extra-embryonic ectoderm, which displays reduced neighbour exchange and in which Dvl2 is excluded specifically from the plasma membrane. Though a single continuous sheet, these two regions of VE show distinct patterns of F-actin localisation, in cortical rings and an apical shroud, respectively. We genetically perturb PCP signalling and show that this disrupts the localisation pattern of Dvl2 and F-actin and the normal migration of AVE cells. In Nodal null embryos, membrane localisation of Dvl2 is reduced, while in mutants for the Nodal inhibitor Lefty1, Dvl2 is ectopically membrane localised, establishing a role for Nodal in modulating PCP signalling. These results show that the limits of AVE migration are determined by regional differences in cell behaviour and protein localisation within an otherwise apparently uniform VE. In addition to coordinating global cell movements across epithelia (such as during convergence extension), PCP signalling in interplay with TGFβ signalling can demarcate regions of differing behaviour within epithelia, thereby modulating the movement of cells within them." @default.
• W2061818013 created "2016-06-24" @default.
• W2061818013 creator A5008877324 @default.
• W2061818013 creator A5017085176 @default.
• W2061818013 creator A5021023928 @default.
• W2061818013 creator A5026590052 @default.
• W2061818013 creator A5036989854 @default.
• W2061818013 creator A5064040469 @default.
• W2061818013 creator A5078393139 @default.
• W2061818013 creator A5083155069 @default.
• W2061818013 date "2011-02-22" @default.
• W2061818013 modified "2023-09-23" @default.
• W2061818013 title "Nodal Dependent Differential Localisation of Dishevelled-2 Demarcates Regions of Differing Cell Behaviour in the Visceral Endoderm" @default.
• W2061818013 cites W1571217264 @default.
• W2061818013 cites W159742518 @default.
• W2061818013 cites W1967065086 @default.
• W2061818013 cites W1968931587 @default.
• W2061818013 cites W1974313494 @default.
• W2061818013 cites W1976454329 @default.
• W2061818013 cites W1981378181 @default.
• W2061818013 cites W1982074654 @default.
• W2061818013 cites W1986202108 @default.
• W2061818013 cites W1987509690 @default.
• W2061818013 cites W1996694167 @default.
• W2061818013 cites W1997864509 @default.
• W2061818013 cites W1998166790 @default.
• W2061818013 cites W2000679474 @default.
• W2061818013 cites W2000775801 @default.
• W2061818013 cites W2003267140 @default.
• W2061818013 cites W2006671195 @default.
• W2061818013 cites W2009234826 @default.
• W2061818013 cites W2010856041 @default.
• W2061818013 cites W2015766782 @default.
• W2061818013 cites W2028456873 @default.
• W2061818013 cites W2039117468 @default.
• W2061818013 cites W2044065327 @default.
• W2061818013 cites W2045523681 @default.
• W2061818013 cites W2048638417 @default.
• W2061818013 cites W2050064867 @default.
• W2061818013 cites W2056922353 @default.
• W2061818013 cites W2057375692 @default.
• W2061818013 cites W2062357508 @default.
• W2061818013 cites W2069693786 @default.
• W2061818013 cites W2069925342 @default.
• W2061818013 cites W2070660616 @default.
• W2061818013 cites W2070700342 @default.
• W2061818013 cites W2077765163 @default.
• W2061818013 cites W2084105838 @default.
• W2061818013 cites W2092178332 @default.
• W2061818013 cites W2095279957 @default.
• W2061818013 cites W2103668136 @default.
• W2061818013 cites W2109627278 @default.
• W2061818013 cites W2113998165 @default.
• W2061818013 cites W2117814548 @default.
• W2061818013 cites W2120983879 @default.
• W2061818013 cites W2125545718 @default.
• W2061818013 cites W2129835280 @default.
• W2061818013 cites W2134160463 @default.
• W2061818013 cites W2140582539 @default.
• W2061818013 cites W2169020003 @default.
• W2061818013 doi "https://doi.org/10.1371/journal.pbio.1001019" @default.
• W2061818013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3042994" @default.
• W2061818013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21364967" @default.
• W2061818013 hasPublicationYear "2011" @default.
• W2061818013 type Work @default.
• W2061818013 sameAs 2061818013 @default.
• W2061818013 citedByCount "46" @default.
• W2061818013 countsByYear W20618180132012 @default.
• W2061818013 countsByYear W20618180132013 @default.
• W2061818013 countsByYear W20618180132014 @default.
• W2061818013 countsByYear W20618180132015 @default.
• W2061818013 countsByYear W20618180132016 @default.
• W2061818013 countsByYear W20618180132017 @default.
• W2061818013 countsByYear W20618180132018 @default.
• W2061818013 countsByYear W20618180132020 @default.
• W2061818013 countsByYear W20618180132021 @default.
• W2061818013 countsByYear W20618180132022 @default.
• W2061818013 countsByYear W20618180132023 @default.
• W2061818013 crossrefType "journal-article" @default.
• W2061818013 hasAuthorship W2061818013A5008877324 @default.
• W2061818013 hasAuthorship W2061818013A5017085176 @default.
• W2061818013 hasAuthorship W2061818013A5021023928 @default.
• W2061818013 hasAuthorship W2061818013A5026590052 @default.
• W2061818013 hasAuthorship W2061818013A5036989854 @default.
• W2061818013 hasAuthorship W2061818013A5064040469 @default.
• W2061818013 hasAuthorship W2061818013A5078393139 @default.
• W2061818013 hasAuthorship W2061818013A5083155069 @default.
• W2061818013 hasBestOaLocation W20618180131 @default.
• W2061818013 hasConcept C104317684 @default.
• W2061818013 hasConcept C105702510 @default.
• W2061818013 hasConcept C107300179 @default.
• W2061818013 hasConcept C129536746 @default.
• W2061818013 hasConcept C137620995 @default.
• W2061818013 hasConcept C137738243 @default.
• W2061818013 hasConcept C145103041 @default.
• W2061818013 hasConcept C1491633281 @default.
• W2061818013 hasConcept C196843134 @default.
• W2061818013 hasConcept C205583638 @default.

• next