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- W2061822687 abstract "Abstract Aberrant activation of Wnt/β-catenin signalling via genetic errors within β-catenin or APC has a crucial role in carcinogenesis. Here, we studied two xanthones, α- and γ-mangostin, as inhibitors of Wnt/β-catenin signalling. The mangostins inhibited TCF/β-catenin transcriptional activity. The mangostins also inhibited protein expression of β-catenin in colon cancer cells, but the inhibition was independent of the phosphorylation and degradation of β-catenin. Instead, the mangostins increased the levels of cGMP and cGMP-dependent kinase, indicating that the inhibition of β-catenin resulted from β-catenin gene regulation. Our results indicate that mangostins could be potential candidates for preventing colon cancer through a novel mechanism of inhibiting Wnt/β-catenin signalling." @default.
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- W2061822687 date "2011-12-01" @default.
- W2061822687 modified "2023-09-27" @default.
- W2061822687 title "α- and γ-Mangostin inhibit the proliferation of colon cancer cells via β-catenin gene regulation in Wnt/cGMP signalling" @default.
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- W2061822687 doi "https://doi.org/10.1016/j.foodchem.2011.06.007" @default.
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