FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061824162> ?p ?o ?g. }

• W2061824162 endingPage "483" @default.
• W2061824162 startingPage "475" @default.
• W2061824162 abstract "Summary The role of the KIAA0391 and PSMA6 genes in predisposing individuals to disease is still not fully understood. We evaluated by molecular beacon‐based genotyping assays the roles of five single nucleotide polymorphisms (SNPs) in the chromosomal region 14q13.2 harbouring the KIAA0391 and PSMA6 gene cluster in coronary artery disease (CAD) in the Saudi population. Two of the studied SNPs rs8008319 (denoted as 1) and rs7157492 (2), reside in the KIAA0391 locus, two others rs1048990 (3) and rs12878391 (4) are components of the PSMA6 , while rs4981283 (5) resides downstream of both genes. In a study involving 1071 patients and 929 controls, none of the studied SNPs showed significant association with CAD. In contrast, two haplotypes consisting of 1A‐2G‐3C‐4A‐5A [O.R.(95% C.I.) = 1.49(0.95–2.35); p = 0.022] and 1A‐2G‐3G‐4A‐5A [2.24(0.84–5.98); p = 0.031] conferred risk for both CAD and myocardial infarction (MI) in a five‐SNP locus model, while another comprising 1A‐2G‐3C‐4A‐5G [2.24(0.84–5.98); p = 0.079] showed a borderline association. One haplotype consisting of 1T‐2G‐3C‐4G‐5A [0.79(0.59–1.05); p = 0.015] exhibited protective properties and another, 1T‐2G‐3C‐4A‐5G [0.20(0.03–139); p = 0.073], showed a similar but weaker trend. Our study identified haplotypes in the chromosomal region encompassing the KIAA0391 and PSMA6 genes as a possible genetic link between CAD and MI. These results also suggest that haplotypes may be more informative than individual SNPs in identifying risk factors for disease." @default.
• W2061824162 created "2016-06-24" @default.
• W2061824162 creator A5004492595 @default.
• W2061824162 creator A5047229520 @default.
• W2061824162 creator A5047995615 @default.
• W2061824162 creator A5053866155 @default.
• W2061824162 creator A5069149655 @default.
• W2061824162 creator A5069352424 @default.
• W2061824162 creator A5086186248 @default.
• W2061824162 creator A5091075403 @default.
• W2061824162 date "2009-08-06" @default.
• W2061824162 modified "2023-09-30" @default.
• W2061824162 title "Haplotypes Encompassing the<i>KIAA0391</i>and<i>PSMA6</i>Gene Cluster Confer a Genetic Link for Myocardial Infarction and Coronary Artery Disease" @default.
• W2061824162 cites W1484475307 @default.
• W2061824162 cites W1536763098 @default.
• W2061824162 cites W1977290507 @default.
• W2061824162 cites W1977760241 @default.
• W2061824162 cites W198220950 @default.
• W2061824162 cites W2007612587 @default.
• W2061824162 cites W2008494755 @default.
• W2061824162 cites W2010725016 @default.
• W2061824162 cites W2011097587 @default.
• W2061824162 cites W2016827868 @default.
• W2061824162 cites W2019263396 @default.
• W2061824162 cites W2020121797 @default.
• W2061824162 cites W2028142113 @default.
• W2061824162 cites W2028517248 @default.
• W2061824162 cites W2036198235 @default.
• W2061824162 cites W2058714321 @default.
• W2061824162 cites W2078492456 @default.
• W2061824162 cites W2084387804 @default.
• W2061824162 cites W2085847856 @default.
• W2061824162 cites W2090430326 @default.
• W2061824162 cites W2090604709 @default.
• W2061824162 cites W2092321951 @default.
• W2061824162 cites W2094058959 @default.
• W2061824162 cites W2100419832 @default.
• W2061824162 cites W2104474839 @default.
• W2061824162 cites W2108453561 @default.
• W2061824162 cites W2124311371 @default.
• W2061824162 cites W2128786825 @default.
• W2061824162 cites W2131373344 @default.
• W2061824162 cites W2135204182 @default.
• W2061824162 cites W2158490907 @default.
• W2061824162 cites W2536400927 @default.
• W2061824162 cites W3064710101 @default.
• W2061824162 doi "https://doi.org/10.1111/j.1469-1809.2009.00534.x" @default.
• W2061824162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19624571" @default.
• W2061824162 hasPublicationYear "2009" @default.
• W2061824162 type Work @default.
• W2061824162 sameAs 2061824162 @default.
• W2061824162 citedByCount "17" @default.
• W2061824162 countsByYear W20618241622012 @default.
• W2061824162 countsByYear W20618241622013 @default.
• W2061824162 countsByYear W20618241622014 @default.
• W2061824162 countsByYear W20618241622018 @default.
• W2061824162 countsByYear W20618241622020 @default.
• W2061824162 countsByYear W20618241622021 @default.
• W2061824162 countsByYear W20618241622022 @default.
• W2061824162 crossrefType "journal-article" @default.
• W2061824162 hasAuthorship W2061824162A5004492595 @default.
• W2061824162 hasAuthorship W2061824162A5047229520 @default.
• W2061824162 hasAuthorship W2061824162A5047995615 @default.
• W2061824162 hasAuthorship W2061824162A5053866155 @default.
• W2061824162 hasAuthorship W2061824162A5069149655 @default.
• W2061824162 hasAuthorship W2061824162A5069352424 @default.
• W2061824162 hasAuthorship W2061824162A5086186248 @default.
• W2061824162 hasAuthorship W2061824162A5091075403 @default.
• W2061824162 hasBestOaLocation W20618241621 @default.
• W2061824162 hasConcept C104317684 @default.
• W2061824162 hasConcept C126322002 @default.
• W2061824162 hasConcept C135763542 @default.
• W2061824162 hasConcept C139275648 @default.
• W2061824162 hasConcept C153209595 @default.
• W2061824162 hasConcept C180754005 @default.
• W2061824162 hasConcept C197754878 @default.
• W2061824162 hasConcept C2778213512 @default.
• W2061824162 hasConcept C2908647359 @default.
• W2061824162 hasConcept C2910535243 @default.
• W2061824162 hasConcept C31467283 @default.
• W2061824162 hasConcept C500558357 @default.
• W2061824162 hasConcept C54355233 @default.
• W2061824162 hasConcept C71924100 @default.
• W2061824162 hasConcept C84597430 @default.
• W2061824162 hasConcept C86803240 @default.
• W2061824162 hasConcept C99454951 @default.
• W2061824162 hasConceptScore W2061824162C104317684 @default.
• W2061824162 hasConceptScore W2061824162C126322002 @default.
• W2061824162 hasConceptScore W2061824162C135763542 @default.
• W2061824162 hasConceptScore W2061824162C139275648 @default.
• W2061824162 hasConceptScore W2061824162C153209595 @default.
• W2061824162 hasConceptScore W2061824162C180754005 @default.
• W2061824162 hasConceptScore W2061824162C197754878 @default.
• W2061824162 hasConceptScore W2061824162C2778213512 @default.
• W2061824162 hasConceptScore W2061824162C2908647359 @default.
• W2061824162 hasConceptScore W2061824162C2910535243 @default.
• W2061824162 hasConceptScore W2061824162C31467283 @default.
• W2061824162 hasConceptScore W2061824162C500558357 @default.

• next