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- W2061824357 abstract "Does combined adrenocortical - androgen steroid therapy potentiate the patient's response to chemotherapy for pulmonary tuberculosis? An attempt was made to evaluate this in a group of 20 patients. All had active disease, one-half never had previous antimicrobial therapy (Group A); the other half had apparently reached the maximum benefit of such therapy (Group B). Adrenocortical-androgen therapy was given to all in a uniform manner for 12 weeks together with chemotherapy for tuberculosis. In addition to the usual clinical, radiologic and sputum examinations, ancillary studies pertaining to glucose tolerance and serum globulins were made in these patients prior to, during and after the discontinuance of the steroids. The data collected were compared with a comparable group of patients studied previously who did not receive steroids. Untoward side effects and results of treatment in both groups are recorded three to 20 months (average 11.5 months) after cessation of the steroid drugs. Three patients died and the causes are cited. In the patients studied, the addition of the adrenocortical-androgen supplements did not appear to produce significant potentiated effects above and beyond what we have seen chemotherapy alone do. However, some weight gain occurred in about 50 per cent of the patients. This response can often be achieved in such patients with an anabolic steroid preparation alone, without resorting to the more hazardous use of adrenocortical steroids. The pros and cons of such adjunctive treatment are discussed and indications for their use in tuberculosis are suggested." @default.
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- W2061824357 date "1962-02-01" @default.
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- W2061824357 title "The Effect of Adrenocortical and Androgenic Steroid Supplements in Tuberculous Patients Receiving Chemotherapy" @default.
- W2061824357 doi "https://doi.org/10.1378/chest.41.2.150" @default.
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