FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061829501> ?p ?o ?g. }

• W2061829501 endingPage "1691" @default.
• W2061829501 startingPage "1681" @default.
• W2061829501 abstract "Delta like 1 homolog (Dlk1) exists in both transmembrane and soluble molecular forms, and is implicated in cellular growth and plays multiple roles in development, tissue regeneration, and cancer. Thus, DLK1 levels are critical for cell function, and abnormal DLK1 expression can be lethal; however, little is known about the underlying mechanisms. We here report that miR-15a modulates DLK1 levels in preadipocytes thus providing a mechanism for DLK1 regulation that further links it to cell cycle arrest and cancer since miR-15a is deregulated in these processes. In preadipocytes, miR-15a increases with cell density, and peaks at the same stage where membrane DLK1(M) and soluble DLK1(S) are found at maximum levels. Remarkably, miR-15a represses the amount of all Dlk1 variants at the mRNA level but also the level of DLK1(M) protein while it increases the amount of DLK1(S) supporting a direct repression of DLK1 and a parallel effect on the protease that cleaves off the DLK1 from the membrane. In agreement with previous studies, we found that miR-15a represses cell numbers, but additionally, we report that miR-15a also increases cell size. Conversely, anti-miR-15a treatment decreases cell size while increasing cell numbers, scenarios that were completely rescued by addition of purified DLK1(S). Our data thus imply that miR-15a regulates cell size and proliferation by fine-tuning Dlk1 among others, and further emphasize miR-15a and DLK1 levels to play important roles in growth signaling networks." @default.
• W2061829501 created "2016-06-24" @default.
• W2061829501 creator A5005600302 @default.
• W2061829501 creator A5006873916 @default.
• W2061829501 creator A5020558434 @default.
• W2061829501 creator A5046533529 @default.
• W2061829501 creator A5052580896 @default.
• W2061829501 creator A5059802318 @default.
• W2061829501 creator A5082281193 @default.
• W2061829501 creator A5091321124 @default.
• W2061829501 date "2010-06-01" @default.
• W2061829501 modified "2023-10-11" @default.
• W2061829501 title "MicroRNA-15a fine-tunes the level of Delta-like 1 homolog (DLK1) in proliferating 3T3-L1 preadipocytes" @default.
• W2061829501 cites W1520896531 @default.
• W2061829501 cites W1577577364 @default.
• W2061829501 cites W1589576417 @default.
• W2061829501 cites W1591100132 @default.
• W2061829501 cites W1886903604 @default.
• W2061829501 cites W1956103182 @default.
• W2061829501 cites W1965921683 @default.
• W2061829501 cites W1966280378 @default.
• W2061829501 cites W1967553625 @default.
• W2061829501 cites W1967589170 @default.
• W2061829501 cites W1976132376 @default.
• W2061829501 cites W1983942535 @default.
• W2061829501 cites W1984948945 @default.
• W2061829501 cites W1992598298 @default.
• W2061829501 cites W1994937206 @default.
• W2061829501 cites W1996311927 @default.
• W2061829501 cites W1996630410 @default.
• W2061829501 cites W2016109221 @default.
• W2061829501 cites W2019781767 @default.
• W2061829501 cites W2021674088 @default.
• W2061829501 cites W2024167399 @default.
• W2061829501 cites W2024597586 @default.
• W2061829501 cites W2036740170 @default.
• W2061829501 cites W2041264506 @default.
• W2061829501 cites W2046087633 @default.
• W2061829501 cites W2050146183 @default.
• W2061829501 cites W2054197039 @default.
• W2061829501 cites W2056435902 @default.
• W2061829501 cites W2060679900 @default.
• W2061829501 cites W2069009920 @default.
• W2061829501 cites W2070040905 @default.
• W2061829501 cites W2074080709 @default.
• W2061829501 cites W2077452107 @default.
• W2061829501 cites W2080195919 @default.
• W2061829501 cites W2080504370 @default.
• W2061829501 cites W2080825616 @default.
• W2061829501 cites W2083219932 @default.
• W2061829501 cites W2089001345 @default.
• W2061829501 cites W2089106590 @default.
• W2061829501 cites W2090042543 @default.
• W2061829501 cites W2091617948 @default.
• W2061829501 cites W2092077293 @default.
• W2061829501 cites W2095360238 @default.
• W2061829501 cites W2098285533 @default.
• W2061829501 cites W2110348656 @default.
• W2061829501 cites W2111399483 @default.
• W2061829501 cites W2112785261 @default.
• W2061829501 cites W2112944159 @default.
• W2061829501 cites W2115630287 @default.
• W2061829501 cites W2119263162 @default.
• W2061829501 cites W2121572054 @default.
• W2061829501 cites W2128685943 @default.
• W2061829501 cites W2138369394 @default.
• W2061829501 cites W2138581811 @default.
• W2061829501 cites W2138596287 @default.
• W2061829501 cites W2139286697 @default.
• W2061829501 cites W2142310248 @default.
• W2061829501 cites W2144411343 @default.
• W2061829501 cites W2146278947 @default.
• W2061829501 cites W2151868278 @default.
• W2061829501 cites W2159793493 @default.
• W2061829501 cites W2160968516 @default.
• W2061829501 cites W2162674813 @default.
• W2061829501 cites W2166094946 @default.
• W2061829501 cites W2172186946 @default.
• W2061829501 cites W3149869420 @default.
• W2061829501 doi "https://doi.org/10.1016/j.yexcr.2010.04.002" @default.
• W2061829501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20385127" @default.
• W2061829501 hasPublicationYear "2010" @default.
• W2061829501 type Work @default.
• W2061829501 sameAs 2061829501 @default.
• W2061829501 citedByCount "59" @default.
• W2061829501 countsByYear W20618295012012 @default.
• W2061829501 countsByYear W20618295012013 @default.
• W2061829501 countsByYear W20618295012014 @default.
• W2061829501 countsByYear W20618295012015 @default.
• W2061829501 countsByYear W20618295012016 @default.
• W2061829501 countsByYear W20618295012017 @default.
• W2061829501 countsByYear W20618295012018 @default.
• W2061829501 countsByYear W20618295012019 @default.
• W2061829501 countsByYear W20618295012021 @default.
• W2061829501 countsByYear W20618295012022 @default.
• W2061829501 countsByYear W20618295012023 @default.
• W2061829501 crossrefType "journal-article" @default.
• W2061829501 hasAuthorship W2061829501A5005600302 @default.

• next