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- W2061838211 abstract "Nicotinic acetylcholine receptors (nAChRs) are transmembrane receptors, members of the ligand-gated ion channels (LGIC) family, and key component of the neuromuscular junction. On vertebrate they mediate nervous impulse supporting the synaptic mechanism. As a result the nAChR are important targets for the treatment of neurodegenerative diseases such as Alzheimer's, Parkinson's, epilepsy, and schizophrenia (Albequerque et al. 2009)., as well as cardiovascular disease, inflammation (Wang et al 2003), depression, and nicotine addiction. On the past four decades the nAChR have being extensively study, however the relation between detergent solubilization and nAChR stability is still poorly understood. Our work considers the detergent structural features and physical properties to classify the detergents into cholesterol-analogs and phospholipid-analogs; which will be employed to isolates nAChR from Torpedo californica's electroplax tissue. The present study attempt to better understand how detergent solubilization affects the nAChR stability once inserted to the Lipidic Cubic Phase (LCP). We examined the Fractional Mobility (FM) of the nAChR on the LCP through fluorescence recovery after photo bleaching (FRAP) experiments for a 30 days period. Our results show that phospholipid-analog detergents with 16 carbon acyl chains sustain nAChR mobility unchanged for the 30 day period, while in most of cholesterol-analog detergents, the nAChR moility decays on the first 15 to 20 days of the experiment. In addition there is an interesting correlation between the elongation of the acyl chain on phospholipid-analog detergents and an increment on the FM, particularly observed on the Lyso-Foscholine detergent family. This work is supported by NIH Grant 1R01GM098343-01. Luis F. Padilla-Morales and Joel E. Gonzalez Nieves equally contribute to this work and both will be presenters." @default.
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- W2061838211 date "2014-01-01" @default.
- W2061838211 modified "2023-10-03" @default.
- W2061838211 title "Progresive Analysis of nAChR Stability in the Lipidic Cubic Phase: nAChR Detergent Solubilization and Fractional Mobility" @default.
- W2061838211 doi "https://doi.org/10.1016/j.bpj.2013.11.1945" @default.
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