FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061842004> ?p ?o ?g. }

• W2061842004 endingPage "568" @default.
• W2061842004 startingPage "561" @default.
• W2061842004 abstract "<h2>Abstract</h2><h3>Objective.</h3> To determine whether eukaryotic elongation factor 1 alpha 2 (eEF1A2), a transforming gene previously shown to be highly expressed in primary human ovarian tumours, is a prognostic marker. <h3>Methods.</h3> We have used an antibody specific for eEF1A2 to measure eEF1A2 protein expression in 500 primary ovarian tumours in a tissue microarray. We have also ectopically expressed eEF1A2 in SK-OV-3 cells, a clear cell carcinoma line that does not normally express eEF1A2. <h3>Results.</h3> We have shown that eEF1A2 has high expression levels in ∼30% of all primary ovarian tumours. 50% of serous tumours, 30% of endometriod, 19% of mucinous and 8% of clear cell tumours highly express eEF1A2. Ectopic expression of eEF1A2 in the SK-OV-3 clear cell carcinoma line enhances their <i>in vitro</i> proliferative capacity and ability to form tumour-like spheroids in hanging drop culture. Expression of eEF1A2 did not alter sensitivity to anoikis, cisplatin, or taxol. In serous cancer, eEF1A2 is an independent prognostic marker for survival and high eEF1A2 protein expression was associated with increased probability of 20-year survival. <h3>Conclusions.</h3> eEF1A2 is highly expressed in ovarian carcinomas. Its expression enhances cell growth <i>in vitro</i>, and eEF1A2 expression is likely to be a useful ovarian cancer prognostic factor in ovarian cancer patients with serous tumours." @default.
• W2061842004 created "2016-06-24" @default.
• W2061842004 creator A5019480876 @default.
• W2061842004 creator A5043593772 @default.
• W2061842004 creator A5047673937 @default.
• W2061842004 creator A5085086748 @default.
• W2061842004 creator A5085580353 @default.
• W2061842004 date "2008-03-01" @default.
• W2061842004 modified "2023-09-26" @default.
• W2061842004 title "The prognostic significance of elongation factor eEF1A2 in ovarian cancer" @default.
• W2061842004 cites W1493871051 @default.
• W2061842004 cites W1546913480 @default.
• W2061842004 cites W1908801241 @default.
• W2061842004 cites W1964246208 @default.
• W2061842004 cites W1966167142 @default.
• W2061842004 cites W1966714888 @default.
• W2061842004 cites W1972304405 @default.
• W2061842004 cites W1992356221 @default.
• W2061842004 cites W1998971601 @default.
• W2061842004 cites W2000269194 @default.
• W2061842004 cites W2013480667 @default.
• W2061842004 cites W2016756307 @default.
• W2061842004 cites W2026414994 @default.
• W2061842004 cites W2033712039 @default.
• W2061842004 cites W2034978601 @default.
• W2061842004 cites W2040184402 @default.
• W2061842004 cites W2041815339 @default.
• W2061842004 cites W2045113803 @default.
• W2061842004 cites W2070788611 @default.
• W2061842004 cites W2072403360 @default.
• W2061842004 cites W2073265682 @default.
• W2061842004 cites W2074481290 @default.
• W2061842004 cites W2075981998 @default.
• W2061842004 cites W2077462602 @default.
• W2061842004 cites W2082276421 @default.
• W2061842004 cites W2086581082 @default.
• W2061842004 cites W2088716692 @default.
• W2061842004 cites W2095938297 @default.
• W2061842004 cites W2110827195 @default.
• W2061842004 cites W2115954319 @default.
• W2061842004 cites W2119698183 @default.
• W2061842004 cites W2126214612 @default.
• W2061842004 cites W2140551998 @default.
• W2061842004 cites W2148914096 @default.
• W2061842004 doi "https://doi.org/10.1016/j.ygyno.2007.11.019" @default.
• W2061842004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18164751" @default.
• W2061842004 hasPublicationYear "2008" @default.
• W2061842004 type Work @default.
• W2061842004 sameAs 2061842004 @default.
• W2061842004 citedByCount "48" @default.
• W2061842004 countsByYear W20618420042012 @default.
• W2061842004 countsByYear W20618420042013 @default.
• W2061842004 countsByYear W20618420042014 @default.
• W2061842004 countsByYear W20618420042015 @default.
• W2061842004 countsByYear W20618420042016 @default.
• W2061842004 countsByYear W20618420042017 @default.
• W2061842004 countsByYear W20618420042018 @default.
• W2061842004 countsByYear W20618420042019 @default.
• W2061842004 countsByYear W20618420042020 @default.
• W2061842004 countsByYear W20618420042022 @default.
• W2061842004 countsByYear W20618420042023 @default.
• W2061842004 crossrefType "journal-article" @default.
• W2061842004 hasAuthorship W2061842004A5019480876 @default.
• W2061842004 hasAuthorship W2061842004A5043593772 @default.
• W2061842004 hasAuthorship W2061842004A5047673937 @default.
• W2061842004 hasAuthorship W2061842004A5085086748 @default.
• W2061842004 hasAuthorship W2061842004A5085580353 @default.
• W2061842004 hasConcept C121608353 @default.
• W2061842004 hasConcept C126322002 @default.
• W2061842004 hasConcept C142724271 @default.
• W2061842004 hasConcept C143998085 @default.
• W2061842004 hasConcept C150173356 @default.
• W2061842004 hasConcept C193270364 @default.
• W2061842004 hasConcept C204232928 @default.
• W2061842004 hasConcept C2780427987 @default.
• W2061842004 hasConcept C3019054536 @default.
• W2061842004 hasConcept C502942594 @default.
• W2061842004 hasConcept C54355233 @default.
• W2061842004 hasConcept C71924100 @default.
• W2061842004 hasConcept C81885089 @default.
• W2061842004 hasConcept C86803240 @default.
• W2061842004 hasConceptScore W2061842004C121608353 @default.
• W2061842004 hasConceptScore W2061842004C126322002 @default.
• W2061842004 hasConceptScore W2061842004C142724271 @default.
• W2061842004 hasConceptScore W2061842004C143998085 @default.
• W2061842004 hasConceptScore W2061842004C150173356 @default.
• W2061842004 hasConceptScore W2061842004C193270364 @default.
• W2061842004 hasConceptScore W2061842004C204232928 @default.
• W2061842004 hasConceptScore W2061842004C2780427987 @default.
• W2061842004 hasConceptScore W2061842004C3019054536 @default.
• W2061842004 hasConceptScore W2061842004C502942594 @default.
• W2061842004 hasConceptScore W2061842004C54355233 @default.
• W2061842004 hasConceptScore W2061842004C71924100 @default.
• W2061842004 hasConceptScore W2061842004C81885089 @default.
• W2061842004 hasConceptScore W2061842004C86803240 @default.
• W2061842004 hasIssue "3" @default.
• W2061842004 hasLocation W20618420041 @default.
• W2061842004 hasLocation W20618420042 @default.

• next