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- W2061842603 abstract "The CyclinB1-Cdk1 kinase is the catalytic activity at the heart of mitosis-promoting factor (MPF), yet fundamental questions concerning its role in mitosis remained unresolved. It is not known when and how rapidly CyclinB1-Cdk1 is activated in mammalian cells, nor how its activation coordinates the substantial changes in the cell at mitosis. Here, we have developed a FRET biosensor specific for CyclinB1-Cdk1 that enables us to assay its activity with very high temporal precision in living human cells. We show that CyclinB1-Cdk1 is inactive in G2 phase and activated at a set time before nuclear envelope breakdown, thereby initiating the events of prophase. CyclinB1-Cdk1 levels rise to their maximum extent over the course of approximately 30 min, and we demonstrate that different levels of CyclinB1-Cdk1 kinase activity trigger different mitotic events, thus revealing how the remarkable reorganization of the cell is coordinated at mitotic entry." @default.
- W2061842603 created "2016-06-24" @default.
- W2061842603 creator A5046956793 @default.
- W2061842603 creator A5080460501 @default.
- W2061842603 date "2010-04-01" @default.
- W2061842603 modified "2023-10-10" @default.
- W2061842603 title "Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis" @default.
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- W2061842603 doi "https://doi.org/10.1016/j.devcel.2010.02.013" @default.
- W2061842603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3325599" @default.
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