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- W2061851617 endingPage "95" @default.
- W2061851617 startingPage "79" @default.
- W2061851617 abstract "Immunotoxins combining antibody specificity with bacterial or plant toxins are limited by their strong immunogenicity and non-specific toxicity. Ribonucleases of the RNase A protein superfamily provide a solution to address these issues because they show potent antineoplastic activity on cell internalization but do not show appreciable immunogenicity or non-specific toxicity. Their therapeutic value is demonstrated by RNase derived from the frog (Rana pipiens), Onconase (ONC, Alfacell, Inc., New Jersey, USA), the first and only RNase being evaluated in clinical trials at present. Conjugation or fusion of RNases to tumor specific antibodies is a promising approach to further boost tumor cell killing of these compounds. This review focuses on 'targeted RNases/ImmunoRNases' as promising novel anticancer therapeutics." @default.
- W2061851617 created "2016-06-24" @default.
- W2061851617 creator A5043280562 @default.
- W2061851617 creator A5044089291 @default.
- W2061851617 creator A5044600024 @default.
- W2061851617 creator A5076562355 @default.
- W2061851617 creator A5088227068 @default.
- W2061851617 date "2008-12-08" @default.
- W2061851617 modified "2023-10-17" @default.
- W2061851617 title "Targeted therapeutic RNases (ImmunoRNases)" @default.
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