Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061852928> ?p ?o ?g. }
- W2061852928 endingPage "293" @default.
- W2061852928 startingPage "285" @default.
- W2061852928 abstract "The effect of thrombin on components of the plasminogen activator (PA)/plasmin pathway in osteoblast-like cells has been investigated. Thrombin was found to increase PA inhibitor-1 (PAI-1) mRNA and protein in a time- and dose-dependent manner. Tissue-type plasminogen activator (t-PA) activity was inhibited in a time- and dose-dependent manner but there was no alteration of t-PA steady-state mRNA levels. Therefore it is likely that the inhibition of t-PA activity was due entirely to the inhibition of t-PA by PAI-1. Thrombin induced a small but consistent transient increase in both urokinase-type plasminogen activator (u-PA) and u-PA receptor mRNA levels but no u-PA activity was detectable by the amidolytic assay used here. The thrombin and u-PAI inhibitor protease nexin (PN-1), present in high levels constitutively in these cells, was found to be unaltered by thrombin treatment. The effects of thrombin on PAI-1 mRNA and protein and t-PA activity appear to be mediated by the thrombin receptor since the thrombin receptor activating peptide, SFLLRN (single letter code for amino acids), was able to mimic the effects of thrombin. Thrombin has been reported to induce prostaglandin synthesis in rat osteoblasts, and several actions of thrombin on osteoblasts have been reported to be partially dependent on prostaglandin synthesis. However, the effects of both thrombin and SFLLRN on PAI-1 protein were found to be independent of prostaglandin synthesis." @default.
- W2061852928 created "2016-06-24" @default.
- W2061852928 creator A5062182823 @default.
- W2061852928 creator A5069853428 @default.
- W2061852928 date "1996-09-01" @default.
- W2061852928 modified "2023-10-11" @default.
- W2061852928 title "Receptor-mediated effect of thrombin on plasminogen activator inhibitor-1 synthesis in rat osteoblast-like cells" @default.
- W2061852928 cites W1485590137 @default.
- W2061852928 cites W1493910160 @default.
- W2061852928 cites W1538605908 @default.
- W2061852928 cites W1589957034 @default.
- W2061852928 cites W1604280489 @default.
- W2061852928 cites W1670027677 @default.
- W2061852928 cites W1970868144 @default.
- W2061852928 cites W1974208990 @default.
- W2061852928 cites W1975077689 @default.
- W2061852928 cites W1987954100 @default.
- W2061852928 cites W1994551148 @default.
- W2061852928 cites W1995426451 @default.
- W2061852928 cites W2001116495 @default.
- W2061852928 cites W2003279840 @default.
- W2061852928 cites W2003948599 @default.
- W2061852928 cites W2004269787 @default.
- W2061852928 cites W2009835323 @default.
- W2061852928 cites W2012113693 @default.
- W2061852928 cites W2015806807 @default.
- W2061852928 cites W2027232333 @default.
- W2061852928 cites W2027851510 @default.
- W2061852928 cites W2030423800 @default.
- W2061852928 cites W2034360673 @default.
- W2061852928 cites W2038483635 @default.
- W2061852928 cites W2040882780 @default.
- W2061852928 cites W2052700106 @default.
- W2061852928 cites W2056755930 @default.
- W2061852928 cites W2063145549 @default.
- W2061852928 cites W2071676754 @default.
- W2061852928 cites W2073261011 @default.
- W2061852928 cites W2074384162 @default.
- W2061852928 cites W2075259524 @default.
- W2061852928 cites W2085864430 @default.
- W2061852928 cites W2089564596 @default.
- W2061852928 cites W2096312838 @default.
- W2061852928 cites W2318157174 @default.
- W2061852928 cites W2329074821 @default.
- W2061852928 cites W2410799312 @default.
- W2061852928 cites W2418284702 @default.
- W2061852928 cites W28773382 @default.
- W2061852928 cites W4233224025 @default.
- W2061852928 cites W4234471753 @default.
- W2061852928 cites W4294216491 @default.
- W2061852928 doi "https://doi.org/10.1016/s0268-9499(96)80009-9" @default.
- W2061852928 hasPublicationYear "1996" @default.
- W2061852928 type Work @default.
- W2061852928 sameAs 2061852928 @default.
- W2061852928 citedByCount "7" @default.
- W2061852928 crossrefType "journal-article" @default.
- W2061852928 hasAuthorship W2061852928A5062182823 @default.
- W2061852928 hasAuthorship W2061852928A5069853428 @default.
- W2061852928 hasConcept C126322002 @default.
- W2061852928 hasConcept C134018914 @default.
- W2061852928 hasConcept C153911025 @default.
- W2061852928 hasConcept C170493617 @default.
- W2061852928 hasConcept C181199279 @default.
- W2061852928 hasConcept C185592680 @default.
- W2061852928 hasConcept C2777292125 @default.
- W2061852928 hasConcept C2778886182 @default.
- W2061852928 hasConcept C2779679481 @default.
- W2061852928 hasConcept C2780675426 @default.
- W2061852928 hasConcept C2781071845 @default.
- W2061852928 hasConcept C55493867 @default.
- W2061852928 hasConcept C71924100 @default.
- W2061852928 hasConcept C86803240 @default.
- W2061852928 hasConcept C89560881 @default.
- W2061852928 hasConceptScore W2061852928C126322002 @default.
- W2061852928 hasConceptScore W2061852928C134018914 @default.
- W2061852928 hasConceptScore W2061852928C153911025 @default.
- W2061852928 hasConceptScore W2061852928C170493617 @default.
- W2061852928 hasConceptScore W2061852928C181199279 @default.
- W2061852928 hasConceptScore W2061852928C185592680 @default.
- W2061852928 hasConceptScore W2061852928C2777292125 @default.
- W2061852928 hasConceptScore W2061852928C2778886182 @default.
- W2061852928 hasConceptScore W2061852928C2779679481 @default.
- W2061852928 hasConceptScore W2061852928C2780675426 @default.
- W2061852928 hasConceptScore W2061852928C2781071845 @default.
- W2061852928 hasConceptScore W2061852928C55493867 @default.
- W2061852928 hasConceptScore W2061852928C71924100 @default.
- W2061852928 hasConceptScore W2061852928C86803240 @default.
- W2061852928 hasConceptScore W2061852928C89560881 @default.
- W2061852928 hasIssue "5-6" @default.
- W2061852928 hasLocation W20618529281 @default.
- W2061852928 hasOpenAccess W2061852928 @default.
- W2061852928 hasPrimaryLocation W20618529281 @default.
- W2061852928 hasRelatedWork W1969848891 @default.
- W2061852928 hasRelatedWork W1990806039 @default.
- W2061852928 hasRelatedWork W2027876001 @default.
- W2061852928 hasRelatedWork W2036468924 @default.
- W2061852928 hasRelatedWork W2037076708 @default.
- W2061852928 hasRelatedWork W2165852896 @default.