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• W2061854298 abstract "Purpose: This study was designed to investigate the effects and mechanisms of anal electric stimulation with long pulses on anal sphincter pressure in conscious dogs. Methods: The study was performed after enema in nine healthy female hound dogs and composed of four randomized sessions (“dose”-response, anal electric stimulation only, or with atropine or phentolamine). The anal sphincter pressure was measured by using manometry and quantified by using the area under the contractile curve (mmHg/sec). Anal electric stimulation was performedviaa pair of ring electrodes attached to a manometric catheter. The stimulation parameters in all but dose-response sessions included a frequency of 20 ppm, pulse width of 200 ms, and amplitude of 3 mA. Results: The anal sphincter pressure was 55.7 ± 6 at baseline and increased by 37 percent to 76.4 ± 6.5 during electric stimulation (P= 0.009). The increase of anal pressure during stimulation was positively correlated with the stimulation energy (r= 0.395;P< 0.01). The excitatory effect of electric stimulation was sustained for at least 20 minutes. Atropine did not alter anal pressure and did not abolish the excitatory effect of anal electric stimulation on the sphincter. Phentolamine reduced anal pressure from the baseline value of 50.5 ± 4.7 to 33.1 ± 5.4 (P= 0.019). The electric stimulation induced increase in anal pressure was dropped from 19 ± 2.6 to 9.9 ± 2.8 (P= 0.029) at the presence of phentolamine. Conclusions: Anal electric stimulation with long pulses increases anal sphincter pressure in an energy-dependent manner. The α-adrenergic but not the cholinergic pathway at least partially mediates the excitatory effect of anal electric stimulation." @default.
• W2061854298 created "2016-06-24" @default.
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• W2061854298 date "2006-03-01" @default.
• W2061854298 modified "2023-09-27" @default.
• W2061854298 title "Anal Electrical Stimulation With Long Pulses Increases Anal Sphincter Pressure in Conscious Dogs" @default.
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• W2061854298 doi "https://doi.org/10.1007/s10350-005-0272-9" @default.
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