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- W2061855251 abstract "Alterations in beta-adrenergic receptors (BAR) of human mononuclear leukocytes (MNL) are considered to reflect changes in central noradrenergic function and have been studied in a number of diseases. This paper critically reviews the results of recent studies on MNL-BAR in depression, with particular emphasis on the biochemical and clinical methodologies used. Despite considerable differences in these methods, a number of laboratories report consistent decreases in MNL-BAR density and significantly reduced functional response in patients as compared to controls. These studies used MNL, isolated from patients who had a greater than 14 day drug washout, and BAR-densities were measured in membrane preparations, using full Scatchard analyses, and 125I-ICYP or 3H-DHA as the ligand. Functional response of MNL-BARs was assessed by the determination of isoproterenol-stimulated cyclic AMP accumulation. A comparison of methods used by these groups further indicates that additional biochemical parameters such as lymphocyte preparation and standardized experimental conditions for the binding assays are also important for obtaining consistent results. The clinical methods in rigorous study designs also include clearly stated inclusion/exclusion criteria for patients, and age-, and gender-matched patient-control populations. Whether the reduced MNL-BAR density and function is an inherited abnormality in depressed patients, or results from downregulation by elevated catecholamines is at present not known. Studies are needed to characterize further the changes in MNL-BARs in depression and to evaluate the effects of caetcholamines and hormones on this system. Based on critical assessment of the methods reviewed we propose specific biochemical and clinical guidelines, and recommend, that these be followed in future studies on MNL-BARs in this disease." @default.
- W2061855251 created "2016-06-24" @default.
- W2061855251 creator A5019156904 @default.
- W2061855251 creator A5059724594 @default.
- W2061855251 creator A5077175959 @default.
- W2061855251 date "1990-01-01" @default.
- W2061855251 modified "2023-09-25" @default.
- W2061855251 title "Studies on leukocyte β-adrenergic receptors in depression: A critical appraisal" @default.
- W2061855251 cites W1515847027 @default.
- W2061855251 cites W1550978342 @default.
- W2061855251 cites W1572620483 @default.
- W2061855251 cites W1579093754 @default.
- W2061855251 cites W1603456808 @default.
- W2061855251 cites W1794165588 @default.
- W2061855251 cites W1913485408 @default.
- W2061855251 cites W1964014026 @default.
- W2061855251 cites W1965003179 @default.
- W2061855251 cites W1965174921 @default.
- W2061855251 cites W1967598382 @default.
- W2061855251 cites W1968493849 @default.
- W2061855251 cites W1969225214 @default.
- W2061855251 cites W1970045225 @default.
- W2061855251 cites W1970274497 @default.
- W2061855251 cites W1970539422 @default.
- W2061855251 cites W1971970304 @default.
- W2061855251 cites W1975602167 @default.
- W2061855251 cites W1977047809 @default.
- W2061855251 cites W1977819918 @default.
- W2061855251 cites W1979462466 @default.
- W2061855251 cites W1980480432 @default.
- W2061855251 cites W1983463708 @default.
- W2061855251 cites W1984999504 @default.
- W2061855251 cites W1988311363 @default.
- W2061855251 cites W1990605637 @default.
- W2061855251 cites W1990813020 @default.
- W2061855251 cites W1992277198 @default.
- W2061855251 cites W1993469690 @default.
- W2061855251 cites W1999628086 @default.
- W2061855251 cites W2001256704 @default.
- W2061855251 cites W2003119693 @default.
- W2061855251 cites W2006873483 @default.
- W2061855251 cites W2008005243 @default.
- W2061855251 cites W2008155215 @default.
- W2061855251 cites W2009305043 @default.
- W2061855251 cites W2010443942 @default.
- W2061855251 cites W2013521890 @default.
- W2061855251 cites W2017019385 @default.
- W2061855251 cites W2019725799 @default.
- W2061855251 cites W2021865527 @default.
- W2061855251 cites W2028420559 @default.
- W2061855251 cites W2030758000 @default.
- W2061855251 cites W2031597407 @default.
- W2061855251 cites W2032443261 @default.
- W2061855251 cites W2036090144 @default.
- W2061855251 cites W2039290418 @default.
- W2061855251 cites W2039529214 @default.
- W2061855251 cites W2040111000 @default.
- W2061855251 cites W2040944443 @default.
- W2061855251 cites W2042903281 @default.
- W2061855251 cites W2043813981 @default.
- W2061855251 cites W2046379746 @default.
- W2061855251 cites W2048669565 @default.
- W2061855251 cites W2049165791 @default.
- W2061855251 cites W2050556059 @default.
- W2061855251 cites W2051199089 @default.
- W2061855251 cites W2053059003 @default.
- W2061855251 cites W2056237088 @default.
- W2061855251 cites W2056528694 @default.
- W2061855251 cites W2058329827 @default.
- W2061855251 cites W2059063184 @default.
- W2061855251 cites W2061378977 @default.
- W2061855251 cites W2062558899 @default.
- W2061855251 cites W2066338041 @default.
- W2061855251 cites W2067881512 @default.
- W2061855251 cites W2070839272 @default.
- W2061855251 cites W2072111883 @default.
- W2061855251 cites W2073049438 @default.
- W2061855251 cites W2073377714 @default.
- W2061855251 cites W2075403106 @default.
- W2061855251 cites W2080160557 @default.
- W2061855251 cites W2080378718 @default.
- W2061855251 cites W2080684732 @default.
- W2061855251 cites W2082104338 @default.
- W2061855251 cites W2086193772 @default.
- W2061855251 cites W2086211739 @default.
- W2061855251 cites W2087013987 @default.
- W2061855251 cites W2090334210 @default.
- W2061855251 cites W2091200799 @default.
- W2061855251 cites W2091768417 @default.
- W2061855251 cites W2095491607 @default.
- W2061855251 cites W2095795974 @default.
- W2061855251 cites W2104385293 @default.
- W2061855251 cites W2110021641 @default.
- W2061855251 cites W2114613490 @default.
- W2061855251 cites W2130637651 @default.
- W2061855251 cites W2132522341 @default.
- W2061855251 cites W2137721231 @default.
- W2061855251 cites W2138668829 @default.