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- W2061857603 abstract "There is rapidly growing evidence for the influence of inflammation on the development and progression of Parkinson's disease (PD). N-terminal pro C-type Natriuretic Peptide (NT-proCNP) is a novel potential inflammatory biomarker and has been recently correlated in PD with pro- and anti-inflammatory cytokines, especially TNF-α and IL-10. The study aims to explore serum level of NT-proCNP in group consisted of 132 patients with idiopathic Parkinson's disease (age 59.6±15.l years) and 46 healthy controls (age 58.5±11.5 years). Serum level of NT-proCNP was significantly higher in PD patients than in the control group (p<0.05; PD vs control: mean 3.65±5.5 vs 1.49±0.73, median 1.81 vs 1.46). The serum level of NT-proCNP was directly correlated with the treatment with dopamine agonist (ropinirole) (R=0.38; p<0.05). The higher serum level of NT-proCNP in PD patients being treated with ropinirole suggests a potential proinflammatory characteristic of dopamine agonists." @default.
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- W2061857603 date "2014-04-01" @default.
- W2061857603 modified "2023-10-15" @default.
- W2061857603 title "Ropinirole treatment in Parkinson's disease associated with higher serum level of inflammatory biomarker NT-proCNP" @default.
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- W2061857603 doi "https://doi.org/10.1016/j.neulet.2014.02.053" @default.
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