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- W2061861665 abstract "An enantioseparation high performance liquid chromatographic (HPLC) method was developed and validated to determine d-(+)- and l-(−)-vesamicol in human plasma. The assay involved the use of a solid phase extraction for plasma sample clean up prior to HPLC analysis utilizing a C18 Bond-Elute column. Chromatographic resolution of the vesamicol enantiomers was performed on a vancomycin macrocyclic antibiotic chiral stationary phase (CSP) known as Chirobiotic V with a polar ionic mobile phase (PIM) consisting of methanol:glacial acetic acid:triethylamine (100:0.1:0.05 (v/v/v)) at a flow rate of 1.0 ml/min and UV detection set at 262 nm. All analyses were conducted at ambient temperature. The method was validated over the range of 1–20 μg/ml for each enantiomer concentration (R2>0.999). Recoveries for d-(+)- and l-(−)-vesamicol enantiomers were in the ranges of 96–105% at 3–16 μg/ml level. The method proved to be precise (within-run precision ranged from 1.3 to 2.7% and between-run precision ranged from 1.5 to 3.4%) and accurate (within-run accuracies ranged from 0.8 to 3.4% and between-run accuracies ranged from 1.7 to 5.0%). The limit of quantitation (LOQ) and limit of detection (LOD) for each enantiomer in human plasma were 1.0 and 0.5 μg/ml (S/N=3), respectively." @default.
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- W2061861665 date "2004-05-01" @default.
- W2061861665 modified "2023-09-23" @default.
- W2061861665 title "A validated LC method for the determination of vesamicol enantiomers in human plasma using vancomycin chiral stationary phase and solid phase extraction" @default.
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- W2061861665 doi "https://doi.org/10.1016/j.jpba.2004.01.017" @default.
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