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• W2061868832 abstract "A series of quinoxalinone peptidomimetic derivatives was designed, synthesized, and assayed for their inhibitory activities on metalloproteinase-2 (MMP-2) and aminopeptidase N (APN). The results showed that all of these quinoxalinone derivatives displayed highly selective inhibition against MMP-2 as compared with APN, with IC(50) values in the micromole range. Compound A3 showed comparable MMP-2 inhibitory activities than the positive control LY52, which might be used as a potential lead in future research on anticancer agents." @default.
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• W2061868832 date "2010-02-01" @default.
• W2061868832 modified "2023-10-16" @default.
• W2061868832 title "Novel matrix metalloproteinase inhibitors derived from quinoxalinone scaffold (Part I)" @default.
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• W2061868832 doi "https://doi.org/10.1016/j.bmc.2010.01.008" @default.
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