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• W2061873240 abstract "T cells play a central role in the development of diabetes both in man and in the non-obese diabetic (NOD) mouse. Both the CD4+and CD8+subsets of T cells are required for the normal development of IDDM in NOD mice. Islet reactive CD4+T cells play a clear pathogenic role as evidenced from the isolation of diabetogenic CD4+T cell clones. CD8+T cells seem to be involved in the initiation of diabetes as lack of these cells leads to protection from diabetes. We have isolated a GAD65reactive, cytotoxic CD8+T cell clone R1 that produces large quantities of IFNγ and accelerates the onset of insulitis. This clone proliferates and produces IFNγ in response to GAD65presenting APCs and kills GAD65presenting targets. Furthermore, it expresses TNFα, CD25, CD28, CD44, CD45 and LFA1, but not CD95L This is the first example of a GAD65specific CD8+T cell clone that accelerates the onset of the insulitis, although it does not appear to accelerate the onset of diabetes." @default.
• W2061873240 created "2016-06-24" @default.
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• W2061873240 date "2003-03-01" @default.
• W2061873240 modified "2023-09-27" @default.
• W2061873240 title "An islet-homing NOD CD8+cytotoxic T cell clone recognizes GAD65and causes insulitis" @default.
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• W2061873240 doi "https://doi.org/10.1016/s0896-8411(03)00003-9" @default.
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