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• W2061877625 startingPage "8823" @default.
• W2061877625 abstract "The two individual cell membranes of epithelia are functionally coupled, so that changes in apical membrane conductance are paralleled by changes in basolateral K+ conductance. However, the signal that regulates basolateral K+ conductance, thereby coupling the two membranes, is unknown. We tested the hypothesis that the cellular calcium concentration, [Ca2+]c, may regulate basolateral K+ conductance in canine tracheal epithelium, a Cl- -secreting epithelium that shows marked membrane coupling. Three findings support the hypothesis. First, the intracellular Ca2+ antagonist 8-(diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride (TMB-8) attenuated the secretory response. Second, the secretagogue epinephrine increased [Ca2+]c, as measured with quin-2. Third, we found a K+ channel that was activated by Ca2+ on the cytosolic side of the membrane. Thus, cytosolic Ca2+ regulates the basolateral K+ conductance and may be the signal responsible for functional coupling of the two cell membranes." @default.
• W2061877625 created "2016-06-24" @default.
• W2061877625 creator A5015869890 @default.
• W2061877625 creator A5037321572 @default.
• W2061877625 date "1985-12-01" @default.
• W2061877625 modified "2023-09-26" @default.
• W2061877625 title "Intracellular calcium regulates basolateral potassium channels in a chloride-secreting epithelium." @default.
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• W2061877625 doi "https://doi.org/10.1073/pnas.82.24.8823" @default.
• W2061877625 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/391530" @default.
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