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- W2061879076 abstract "DNA-encoded libraries of small organic molecules facilitate the construction of large, encoded self-assembling chemical libraries for the identification of high-affinity binders to protein targets. We have constructed a library of 477 chemical compounds, coupled to 48mer-oligonucleotides, each containing a unique six-base sequence serving as “bar-code” for the identification of the chemical moiety. The functionality of the library was confirmed by selection and amplification of both high- and low-affinity binding molecules specific to streptavidin." @default.
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- W2061879076 date "2006-02-18" @default.
- W2061879076 modified "2023-09-30" @default.
- W2061879076 title "Selection of Streptavidin Binders from a DNA-Encoded Chemical Library" @default.
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- W2061879076 doi "https://doi.org/10.1021/bc050282y" @default.
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