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• W2061888208 abstract "Rats were given 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at dosages of 0, 0.001, 0.01, 0.1, or 1.0 μg/kg, 5 days/wk for 13 wk. Doses of 1.0 μg TCDD/kg/day caused some mortality, inactivity, decreased body weights and food consumption, icterus, increased serum bilirubin and alkaline phosphatase, pathomorphologic changes in the liver, lymphoid depletion of the thymus and other lymphoid organs, increased urinary excretion of porphyrins and delta-aminolevulinic acid, and minimal alterations of some hematopoietic components. Morphological evidence of a functional suppression of the reproductive organs was consistent with either a direct toxic effect of this dose of TCDD, or an indirect toxic effect associated with the poor physical condition of these rats. Doses of 0.1 μg TCDD/kg/day caused decreased body weights and food consumption, and slight degrees of liver degeneration and lymphoid depletion. Other effects seen only in females given this dose level included increases in urinary excretion of coproporphyrin and delta-aminolevulinic acid and increases in serum alkaline phosphatase and bilirubin. Effects seen only in males given this dose level included a depression of some hematologic parameters (packed cell volume, red blood cells, and hemoglobin). In rats given 0.01 or 0.001 μg TCDD/kg/day, all parameters were essentially unaffected, except for a slight increase in the mean liver-to-body-weight ratio in rats given 0.01 μg TCDD/kg/day. This slight increase in relative liver weight was not considered of any toxicological significance. These data indicate that no discernible ill effects occurred in rats given 0.01 or 0.001 μg TCDD/kg 5 days/wk for 13 wk." @default.
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• W2061888208 date "1976-03-01" @default.
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• W2061888208 title "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD): Results of a 13-week oral toxicity study in rats" @default.
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• W2061888208 doi "https://doi.org/10.1016/0041-008x(76)90078-8" @default.
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