FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061899371> ?p ?o ?g. }

• W2061899371 endingPage "412" @default.
• W2061899371 startingPage "389" @default.
• W2061899371 abstract "During the past decade, many significant developments in the clinical management of thrombotic and vascular disorders have occurred. In particular, several newer approaches for the prophylactic and therapeutic management of such disorders as venous thrombosis, acute myocardial infarction and stroke have been introduced. This has only been possible due to the understanding of the molecular mechanisms involved in the thrombogenic process which plays a key role in the pathophysiology of thrombotic and vascular disorders. With the increased knowledge of the pathophysiology of thrombosis have come advances in drug treatment possibilities. Advances in biotechnology and separation techniques have contributed to the development of many newer antithrombotic, anticoagulant and thrombolytic drugs. Many new drugs and devices based on newer concepts are currently being tested in various clinical trials. Hirudin, hirulog, Gpllb/llla targeting antibodies and tissue factor pathway inhibitor (TFPI), are some examples. From these current developments, it can be appreciated that antithrombotic drugs represent a wide spectrum of natural, synthetic, semisynthetic and biotechnology produced agents with marked differences in chemical composition, physico-chemical properties, biochemical actions and pharmacologic effects. The use of physical means to treat thrombotic disorders and advanced means of drug delivery add to the expanding nature of treatment. The endogenous actions of the antithrombotic drugs are quite complex. It is no longer valid to assume that an antithrombotic drug must produce an anticoagulant action in blood, as do the classical heparin and oral anticoagulants. Many of these new drugs do not produce any alteration of currently measurable blood clotting parameters, yet they are effective therapeutic agents because of their interactions with the elements of the blood and the vasculature. Another perspective is that several of these agents require endogenous transformation to become active products. Therefore, it becomes important to rely on the pharmacodynamic actions of these agents rather than on other in vitro characteristics to assess potency or efficacy. Haematologic and vascular modulation play a key role in the mediation of the antithrombotic actions of these drugs involving red cells, white cells, platelets, endothelial cells and blood proteins. Thus, an optimal antithrombotic drug/approach will include the targeting of all possible sites involved in thrombogenesis. Polytherapeutic approaches utilising combinations of drugs may turn out to be the most effective in the management of thrombotic disorders." @default.
• W2061899371 created "2016-06-24" @default.
• W2061899371 creator A5007859032 @default.
• W2061899371 creator A5030457785 @default.
• W2061899371 creator A5050677022 @default.
• W2061899371 creator A5064983817 @default.
• W2061899371 creator A5074304553 @default.
• W2061899371 date "1995-05-01" @default.
• W2061899371 modified "2023-09-25" @default.
• W2061899371 title "Section Review—Cardiovascular & Renal: Recent Developments in Antithrombotic Agents" @default.
• W2061899371 cites W1527283637 @default.
• W2061899371 cites W1552647544 @default.
• W2061899371 cites W1592891623 @default.
• W2061899371 cites W19505608 @default.
• W2061899371 cites W1964858690 @default.
• W2061899371 cites W1967927771 @default.
• W2061899371 cites W1968858495 @default.
• W2061899371 cites W1970619525 @default.
• W2061899371 cites W1971696680 @default.
• W2061899371 cites W1976136580 @default.
• W2061899371 cites W1977398058 @default.
• W2061899371 cites W1994999842 @default.
• W2061899371 cites W1997319204 @default.
• W2061899371 cites W2000202127 @default.
• W2061899371 cites W2000903422 @default.
• W2061899371 cites W2012330153 @default.
• W2061899371 cites W2016642690 @default.
• W2061899371 cites W2019069064 @default.
• W2061899371 cites W2019284089 @default.
• W2061899371 cites W2026624464 @default.
• W2061899371 cites W2028699791 @default.
• W2061899371 cites W2028889338 @default.
• W2061899371 cites W2028906838 @default.
• W2061899371 cites W2033724005 @default.
• W2061899371 cites W2036907646 @default.
• W2061899371 cites W2039658297 @default.
• W2061899371 cites W2040116041 @default.
• W2061899371 cites W2040326987 @default.
• W2061899371 cites W2041082927 @default.
• W2061899371 cites W2043046965 @default.
• W2061899371 cites W2046665728 @default.
• W2061899371 cites W2048028900 @default.
• W2061899371 cites W2048963722 @default.
• W2061899371 cites W2051282408 @default.
• W2061899371 cites W2073923473 @default.
• W2061899371 cites W2085676297 @default.
• W2061899371 cites W2085944794 @default.
• W2061899371 cites W2090279732 @default.
• W2061899371 cites W2093491931 @default.
• W2061899371 cites W2094312297 @default.
• W2061899371 cites W2096022613 @default.
• W2061899371 cites W2130213600 @default.
• W2061899371 cites W2138787652 @default.
• W2061899371 cites W2281557481 @default.
• W2061899371 cites W2338618131 @default.
• W2061899371 cites W2526207712 @default.
• W2061899371 cites W4234520823 @default.
• W2061899371 cites W56239716 @default.
• W2061899371 doi "https://doi.org/10.1517/13543784.4.5.389" @default.
• W2061899371 hasPublicationYear "1995" @default.
• W2061899371 type Work @default.
• W2061899371 sameAs 2061899371 @default.
• W2061899371 citedByCount "19" @default.
• W2061899371 crossrefType "journal-article" @default.
• W2061899371 hasAuthorship W2061899371A5007859032 @default.
• W2061899371 hasAuthorship W2061899371A5030457785 @default.
• W2061899371 hasAuthorship W2061899371A5050677022 @default.
• W2061899371 hasAuthorship W2061899371A5064983817 @default.
• W2061899371 hasAuthorship W2061899371A5074304553 @default.
• W2061899371 hasConcept C126322002 @default.
• W2061899371 hasConcept C177713679 @default.
• W2061899371 hasConcept C203014093 @default.
• W2061899371 hasConcept C2777015399 @default.
• W2061899371 hasConcept C2777292125 @default.
• W2061899371 hasConcept C2778205648 @default.
• W2061899371 hasConcept C2778271848 @default.
• W2061899371 hasConcept C2780035454 @default.
• W2061899371 hasConcept C2780868729 @default.
• W2061899371 hasConcept C2909817843 @default.
• W2061899371 hasConcept C71924100 @default.
• W2061899371 hasConcept C89560881 @default.
• W2061899371 hasConcept C98274493 @default.
• W2061899371 hasConceptScore W2061899371C126322002 @default.
• W2061899371 hasConceptScore W2061899371C177713679 @default.
• W2061899371 hasConceptScore W2061899371C203014093 @default.
• W2061899371 hasConceptScore W2061899371C2777015399 @default.
• W2061899371 hasConceptScore W2061899371C2777292125 @default.
• W2061899371 hasConceptScore W2061899371C2778205648 @default.
• W2061899371 hasConceptScore W2061899371C2778271848 @default.
• W2061899371 hasConceptScore W2061899371C2780035454 @default.
• W2061899371 hasConceptScore W2061899371C2780868729 @default.
• W2061899371 hasConceptScore W2061899371C2909817843 @default.
• W2061899371 hasConceptScore W2061899371C71924100 @default.
• W2061899371 hasConceptScore W2061899371C89560881 @default.
• W2061899371 hasConceptScore W2061899371C98274493 @default.
• W2061899371 hasIssue "5" @default.
• W2061899371 hasLocation W20618993711 @default.
• W2061899371 hasOpenAccess W2061899371 @default.

• next