FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061902023> ?p ?o ?g. }

• W2061902023 endingPage "152" @default.
• W2061902023 startingPage "147" @default.
• W2061902023 abstract "New tandem mass spectrometric method coupled with liquid chromatography (LC-MS/MS) has been developed to determine the total concentration of camptothecin derivatives (irinotecan and SN-38) regardless of inter-conversion phenomenon between carboxylate and lactone forms. At first, all sample solutions were acidified for 1h in order to completely convert CPT derivatives into their lactone forms and then CPT derivatives were extracted with organic solution containing diethyl ether and ethyl acetate (2:1, v/v) just after alkalization in the range pH 8.0-8.5 in acid-treated solutions. Analytes were separated on a reverse phase C18 column (150×2.1mm) and eluted isocratically with a mobile phase which consisted of acetonitrile-methanol-buffer (0.1% formic acid, 5mM ammonium formate) (3:4:3, v/v). CPT derivatives were monitored by tandem mass spectrometry in electrospay-positive ionization and multiple reaction mode programmed to the following transitions (m/z): '587.6→167.2' of CPT-11, '393.6→349.3' of SN-38 and '349.4→ 305.2' of CPT. The method was validated to have the proper linearity (r(2)>0.99) over the range of 5-1000ng/ml of CPT-11 and 1-250ng/ml of SN-38 with good accuracy (89.8-114.3%) and precision (less than 10%). In all stability tests, concentration of CPT-11 and SN-38 had been left in the acceptable range of 88.8-110.7% when sample solutions were acidified before determination of CPT derivatives. Newly developed LC-MS/MS method was suitable for the determination of CPT derivatives of both rabbit plasma and tumor tissues in the pharmacokinetic study." @default.
• W2061902023 created "2016-06-24" @default.
• W2061902023 creator A5015125271 @default.
• W2061902023 creator A5023381192 @default.
• W2061902023 creator A5037758664 @default.
• W2061902023 creator A5046190075 @default.
• W2061902023 creator A5072997760 @default.
• W2061902023 creator A5079001499 @default.
• W2061902023 creator A5089512802 @default.
• W2061902023 creator A5062811132 @default.
• W2061902023 date "2014-07-01" @default.
• W2061902023 modified "2023-10-09" @default.
• W2061902023 title "Determination of irinotecan and its metabolite SN-38 in rabbit plasma and tumors using a validated method of tandem mass spectrometry coupled with liquid chromatography" @default.
• W2061902023 cites W1971056311 @default.
• W2061902023 cites W1972018837 @default.
• W2061902023 cites W1988681679 @default.
• W2061902023 cites W2000540782 @default.
• W2061902023 cites W2009737653 @default.
• W2061902023 cites W2010936618 @default.
• W2061902023 cites W2017941725 @default.
• W2061902023 cites W2018185888 @default.
• W2061902023 cites W2038167908 @default.
• W2061902023 cites W2047432753 @default.
• W2061902023 cites W2067332276 @default.
• W2061902023 cites W2075631864 @default.
• W2061902023 cites W2087126422 @default.
• W2061902023 cites W2087226204 @default.
• W2061902023 cites W2125942822 @default.
• W2061902023 cites W2131063689 @default.
• W2061902023 cites W2246769930 @default.
• W2061902023 doi "https://doi.org/10.1016/j.jchromb.2014.05.042" @default.
• W2061902023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24927278" @default.
• W2061902023 hasPublicationYear "2014" @default.
• W2061902023 type Work @default.
• W2061902023 sameAs 2061902023 @default.
• W2061902023 citedByCount "11" @default.
• W2061902023 countsByYear W20619020232015 @default.
• W2061902023 countsByYear W20619020232016 @default.
• W2061902023 countsByYear W20619020232017 @default.
• W2061902023 countsByYear W20619020232018 @default.
• W2061902023 countsByYear W20619020232021 @default.
• W2061902023 countsByYear W20619020232022 @default.
• W2061902023 crossrefType "journal-article" @default.
• W2061902023 hasAuthorship W2061902023A5015125271 @default.
• W2061902023 hasAuthorship W2061902023A5023381192 @default.
• W2061902023 hasAuthorship W2061902023A5037758664 @default.
• W2061902023 hasAuthorship W2061902023A5046190075 @default.
• W2061902023 hasAuthorship W2061902023A5062811132 @default.
• W2061902023 hasAuthorship W2061902023A5072997760 @default.
• W2061902023 hasAuthorship W2061902023A5079001499 @default.
• W2061902023 hasAuthorship W2061902023A5089512802 @default.
• W2061902023 hasConcept C161790260 @default.
• W2061902023 hasConcept C162356407 @default.
• W2061902023 hasConcept C178790620 @default.
• W2061902023 hasConcept C179998833 @default.
• W2061902023 hasConcept C185592680 @default.
• W2061902023 hasConcept C2775986502 @default.
• W2061902023 hasConcept C2777379063 @default.
• W2061902023 hasConcept C2777463227 @default.
• W2061902023 hasConcept C2779858419 @default.
• W2061902023 hasConcept C2780178953 @default.
• W2061902023 hasConcept C2780782300 @default.
• W2061902023 hasConcept C31827203 @default.
• W2061902023 hasConcept C43617362 @default.
• W2061902023 hasConcept C64489805 @default.
• W2061902023 hasConcept C71043704 @default.
• W2061902023 hasConcept C73826308 @default.
• W2061902023 hasConceptScore W2061902023C161790260 @default.
• W2061902023 hasConceptScore W2061902023C162356407 @default.
• W2061902023 hasConceptScore W2061902023C178790620 @default.
• W2061902023 hasConceptScore W2061902023C179998833 @default.
• W2061902023 hasConceptScore W2061902023C185592680 @default.
• W2061902023 hasConceptScore W2061902023C2775986502 @default.
• W2061902023 hasConceptScore W2061902023C2777379063 @default.
• W2061902023 hasConceptScore W2061902023C2777463227 @default.
• W2061902023 hasConceptScore W2061902023C2779858419 @default.
• W2061902023 hasConceptScore W2061902023C2780178953 @default.
• W2061902023 hasConceptScore W2061902023C2780782300 @default.
• W2061902023 hasConceptScore W2061902023C31827203 @default.
• W2061902023 hasConceptScore W2061902023C43617362 @default.
• W2061902023 hasConceptScore W2061902023C64489805 @default.
• W2061902023 hasConceptScore W2061902023C71043704 @default.
• W2061902023 hasConceptScore W2061902023C73826308 @default.
• W2061902023 hasLocation W20619020231 @default.
• W2061902023 hasLocation W20619020232 @default.
• W2061902023 hasOpenAccess W2061902023 @default.
• W2061902023 hasPrimaryLocation W20619020231 @default.
• W2061902023 hasRelatedWork W1985736144 @default.
• W2061902023 hasRelatedWork W1985805639 @default.
• W2061902023 hasRelatedWork W2031860429 @default.
• W2061902023 hasRelatedWork W2046839958 @default.
• W2061902023 hasRelatedWork W2112409870 @default.
• W2061902023 hasRelatedWork W2288829398 @default.
• W2061902023 hasRelatedWork W2368435838 @default.
• W2061902023 hasRelatedWork W2384991848 @default.
• W2061902023 hasRelatedWork W2513471305 @default.
• W2061902023 hasRelatedWork W2995980153 @default.
• W2061902023 hasVolume "962" @default.

• next