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- W2061903529 abstract "Die Hemmwirkung von 2-Fluor-mevalonsäure auf die Biosynthese des Squalens aus Mevalonsäure wird in vitro mit Hilfe angereicherter Enzyme aus Bäckerhefe untersucht. Eines der 4 Stereoisomeren des Mevalonsäure-Antimetaboliten wird mit ATP zur 5-Phospho- und zur 5-Pyrophospho-2-fluor-mevalonsäure phosphoryliert. Die enzymatische Umwandlung zu 4-Fluor-isopentenylpyrophosphat gelingt jedoch nicht mehr. Die sich auf drei Reaktionsschritte in der Terpensynthese erstreckende kompetitive Hemmwirkung der 2-Fluor-mevalonsäure und ihrer phosphorylierten Derivate führt in vitro bis zu einer 86-proz. Hemmung der Squalensynthese." @default.
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- W2061903529 date "1961-07-13" @default.
- W2061903529 modified "2023-09-23" @default.
- W2061903529 title "Zur Biosynthese der Terpene, XIII. Die Hemmung der biologischen Squalensynthese durch 2-Fluor-mevalonsäure" @default.
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- W2061903529 doi "https://doi.org/10.1002/jlac.19616440107" @default.
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