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• W2061923218 abstract "A focused library approach identifying novel leads to develop a potent ORL1 antagonist is described. Beginning from a compound identified by random screening, an exploratory library that exhibited a diverse display of pharmacophores was designed. After evaluating ORL1 antagonistic activity, a highly focused library was designed based on 3D-pharmacophore similarity to known actives. A novel d-proline amide class was identified in this library and was found to possess potent ORL1 antagonistic activity." @default.
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• W2061923218 date "2006-01-19" @default.
• W2061923218 modified "2023-10-11" @default.
• W2061923218 title "Identification of a Novel Spiropiperidine Opioid Receptor-like 1 Antagonist Class by a Focused Library Approach Featuring 3D-Pharmacophore Similarity" @default.
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• W2061923218 doi "https://doi.org/10.1021/jm0509851" @default.
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