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- W2061931323 abstract "The cortical adicic response to intravenous NaHCO3 in the cat was analyzed critically, and its relation to the blood brain barrier to HCOI was considered. Correct measurement of the response requires intact cortical and piaarachnoid blood vessels, accurate identification and recording of DC and pH potential differences at the brain surface, and control of ventilation. Changes in the response could be quantified and used to demonstrate damage of the blood brain barrier to HCOI. With progressive damage, HCOI probably enters the brain more readily and the acidic response changes until, with severe damage, the response is only alkaline and resembles the alkaline change of the blood following i.v. NaHCO3. Reduction of the response is graded and may depend on the extent and site of vessel damage. The response is resistant to anoxia and metabolic inhibitors, but is reduced by topically applied alcohols and surface active compounds. Analysis of the changes following increasing quantities of concentrated solutions..." @default.
- W2061931323 created "2016-06-24" @default.
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- W2061931323 date "1971-01-01" @default.
- W2061931323 modified "2023-10-16" @default.
- W2061931323 title "The Cortical Acidic Response To Intravenous NahCO3and The Nature of Blood Brain Barrier Damage" @default.
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- W2061931323 doi "https://doi.org/10.3109/00207457109146987" @default.
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