FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2061933400> ?p ?o ?g. }

• W2061933400 endingPage "1758" @default.
• W2061933400 startingPage "1750" @default.
• W2061933400 abstract "Efficient delivery of nanosized drug formulations to the desired body sites is not always reached despite the rapid development of pharmaceutical nanotechnologies. In spite of the undoubted effect of the size for increased bioavailability and controlled drug delivery, submicrometer formulations also require a deeper level of design. The surface properties of the particles determine the stability of the particles, interactions with the body, and targeting potentials of drugs. Thus, the efficacy of the drug can be increased utilizing the surface layer of the nanoparticles. Influencing the surface characters of the drug is the main focus of the present work, which introduces a method for preparing nanoparticles with functional sites from low-solubility drugs using hydrophobin (HFB) proteins. Particles were prepared by precipitating a lipophilic drug (beclomethasone dipropionate) in water in the presence of the HFB proteins. Particle size below 200 nm could easily be reached with increasing HFB concentration. The particles were shown to be stable for at least 5 h in suspension, and they could be stored for longer periods of time after freeze-drying. Labeling studies using green fluorescent protein (GFP) genetically fused to a HFB clearly demonstrated that the surface of the nanoparticles was covered with the hydrophobins and that the surface could be further modified by utilizing fusion proteins. This provides a template for a variety of different functional surface-bound groups that could be tailored by modifying the hydrophilic side of the HFB via protein bioengineering. In this study, the combination of proteins and traditional pharmaceutical technology was used to synthesize functionalized protein-coated nanoparticles for drug delivery purposes." @default.
• W2061933400 created "2016-06-24" @default.
• W2061933400 creator A5004833492 @default.
• W2061933400 creator A5008361958 @default.
• W2061933400 creator A5008612982 @default.
• W2061933400 creator A5019234324 @default.
• W2061933400 creator A5024426748 @default.
• W2061933400 creator A5085039475 @default.
• W2061933400 date "2010-03-08" @default.
• W2061933400 modified "2023-10-18" @default.
• W2061933400 title "Multifunctional Hydrophobin: Toward Functional Coatings for Drug Nanoparticles" @default.
• W2061933400 cites W1963800833 @default.
• W2061933400 cites W1967562539 @default.
• W2061933400 cites W1971559859 @default.
• W2061933400 cites W1971823253 @default.
• W2061933400 cites W1978246377 @default.
• W2061933400 cites W1978734347 @default.
• W2061933400 cites W1986640771 @default.
• W2061933400 cites W1987021779 @default.
• W2061933400 cites W1993903595 @default.
• W2061933400 cites W1994272580 @default.
• W2061933400 cites W1998955917 @default.
• W2061933400 cites W2000909037 @default.
• W2061933400 cites W2004282507 @default.
• W2061933400 cites W2011632679 @default.
• W2061933400 cites W2013341713 @default.
• W2061933400 cites W2016971948 @default.
• W2061933400 cites W2018693859 @default.
• W2061933400 cites W2020699201 @default.
• W2061933400 cites W2021789920 @default.
• W2061933400 cites W2023724685 @default.
• W2061933400 cites W2028519434 @default.
• W2061933400 cites W2032563075 @default.
• W2061933400 cites W2034697702 @default.
• W2061933400 cites W2038375609 @default.
• W2061933400 cites W2039823464 @default.
• W2061933400 cites W2039872518 @default.
• W2061933400 cites W2043045805 @default.
• W2061933400 cites W2052888695 @default.
• W2061933400 cites W2055944585 @default.
• W2061933400 cites W2059225643 @default.
• W2061933400 cites W2059699393 @default.
• W2061933400 cites W2071327322 @default.
• W2061933400 cites W2075994353 @default.
• W2061933400 cites W2077701681 @default.
• W2061933400 cites W2082799192 @default.
• W2061933400 cites W2084435683 @default.
• W2061933400 cites W2086026640 @default.
• W2061933400 cites W2091276107 @default.
• W2061933400 cites W2094399039 @default.
• W2061933400 cites W2095524590 @default.
• W2061933400 cites W2099176294 @default.
• W2061933400 cites W2102037532 @default.
• W2061933400 cites W2103758980 @default.
• W2061933400 cites W2120826143 @default.
• W2061933400 cites W2137548214 @default.
• W2061933400 cites W2162818046 @default.
• W2061933400 cites W2165606420 @default.
• W2061933400 cites W2166819539 @default.
• W2061933400 cites W2167924652 @default.
• W2061933400 cites W4251505294 @default.
• W2061933400 cites W4376849571 @default.
• W2061933400 doi "https://doi.org/10.1021/nn9017558" @default.
• W2061933400 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20210303" @default.
• W2061933400 hasPublicationYear "2010" @default.
• W2061933400 type Work @default.
• W2061933400 sameAs 2061933400 @default.
• W2061933400 citedByCount "120" @default.
• W2061933400 countsByYear W20619334002012 @default.
• W2061933400 countsByYear W20619334002013 @default.
• W2061933400 countsByYear W20619334002014 @default.
• W2061933400 countsByYear W20619334002015 @default.
• W2061933400 countsByYear W20619334002016 @default.
• W2061933400 countsByYear W20619334002017 @default.
• W2061933400 countsByYear W20619334002018 @default.
• W2061933400 countsByYear W20619334002019 @default.
• W2061933400 countsByYear W20619334002020 @default.
• W2061933400 countsByYear W20619334002021 @default.
• W2061933400 countsByYear W20619334002022 @default.
• W2061933400 countsByYear W20619334002023 @default.
• W2061933400 crossrefType "journal-article" @default.
• W2061933400 hasAuthorship W2061933400A5004833492 @default.
• W2061933400 hasAuthorship W2061933400A5008361958 @default.
• W2061933400 hasAuthorship W2061933400A5008612982 @default.
• W2061933400 hasAuthorship W2061933400A5019234324 @default.
• W2061933400 hasAuthorship W2061933400A5024426748 @default.
• W2061933400 hasAuthorship W2061933400A5085039475 @default.
• W2061933400 hasConcept C104317684 @default.
• W2061933400 hasConcept C111368507 @default.
• W2061933400 hasConcept C115537861 @default.
• W2061933400 hasConcept C127313418 @default.
• W2061933400 hasConcept C147789679 @default.
• W2061933400 hasConcept C155574463 @default.
• W2061933400 hasConcept C155672457 @default.
• W2061933400 hasConcept C171250308 @default.
• W2061933400 hasConcept C178790620 @default.
• W2061933400 hasConcept C181389837 @default.
• W2061933400 hasConcept C18150654 @default.

• next