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- W2061946136 abstract "Aquaporin-4 (AQP4) water channel protein transports water molecules across cell membranes bidirectionally and involves in a neurological disorder, neuromyelitis optica (NMO) caused by anti-AQP4 antibodies. Here, we developed a platform based on nanovesicle-carbon nanotube hybrid nanostructures for the real-time detection of anti-AQP4 antibodies and the electrophysiological monitoring of AQP4 activities. Using the hybrid device, we could detect anti-AQP4 antibodies with a high sensitivity and estimate the binding constants under different osmotic conditions. The results show AQP4 had a better affinity to anti-AQP4 antibodies under hyper-osmotic conditions than normal conditions. Furthermore, our device can be utilized to study the real-time cellular responses related with AQP4 such as those to different osmotic stresses. This nanovesicle-based platform can be a simple but versatile tool for basic research about AQP4 and related biomedical applications such as disease diagnostics." @default.
- W2061946136 created "2016-06-24" @default.
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- W2061946136 date "2014-11-01" @default.
- W2061946136 modified "2023-10-12" @default.
- W2061946136 title "Nanovesicle-based platform for the electrophysiological monitoring of aquaporin-4 and the real-time detection of its antibody" @default.
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- W2061946136 doi "https://doi.org/10.1016/j.bios.2014.05.003" @default.
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