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- W2061946465 abstract "Abstract: Our previous study demonstrated thalidomide-induced anencephaly and holoprocencephaly at a high frequency in JW-NIBS rabbits. In order to know the early morphogenetic process of these two malformations, thalidomide was orally given to pregnant JW-NIBS rabbits on day 7 or on days 6–9 of gestation, and the embryos were examined on days 9–13 in histological sections and scanning electronmicroscopic specimens. The preponderant site of thalidomide-induced dysraphic change was the midfrontal portion of the prosencephalic vesicle. A widely opened cephalic neural tube at this portion and consequent eversion of the telencephalic wall observed in day-9-embryos (231 hours postcoitus) was the first change of most anencephaly in this experiment. Incomplete closure of the cephalic neural tube under the closed surface ectoderm observed at the midfrontal portion of day-9-embryos was divided into two types: One type showed a contact of the neural folds but no histological continuation, and the other type evidenced a degeneration of the neuroepithelial tissue at the closing site and hypoplasia of the surrounding mesenchymal tissue. The mesenchymal tissue over the neuroepithelial layer showed curled cellular processes and a loose interconnection in scanning electronmicroscopic specimens. The midfrontal encephalocele observed in day-13-embryos could be regarded as the consequence of the former type of incomplete closure. Defective formation of the longitudinal fissure of the telencephalon due to the midfrontal encephalocele was the cause of holoprosencephaly later. Not only unclosure of the neural tube but also the latter type of incomplete closure was considered to manifest anencephaly." @default.
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- W2061946465 date "1990-03-01" @default.
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- W2061946465 title "Morphogenetic process of dysraphic malformations induced by thalidomide in JW-NIBS rabbits" @default.
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- W2061946465 doi "https://doi.org/10.1111/j.1741-4520.1990.tb00494.x" @default.
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